Therapeutic monoclonal antibodies (mAbs) have made a tremendous impact in treating
patients with various diseases. MAbs are designed to specifically target a cell and illicit a …

This study shows that state-of-the-art liquid chromatography (LC) and mass spectrometry
(MS) can be used for rapid verification of identity and characterization of sequence variants …

One of the fastest growing segments in the biopharmaceutical market is biosimilars. This
emerging biotech sector requires novel bioanalytical tools to address the challenging …

Currently, there are more than 58 antibodies clinically available for the treatment of various
diseases, including cancer, chronic inflammation and infection. In 2016, eight antibodies …

Liquid chromatography–tandem mass spectrometry-based proteomics for peptide mapping
and sequencing was used to characterize the marketed monoclonal antibody trastuzumab …

Addressing a significant need by describing the science and process involved to develop
biosimilars of monoclonal antibody (mAb) drugs, this book covers all aspects of biosimilar …

Liquid chromatography mass spectrometry (LC–MS) is the most commonly used technique
for the characterization of antibody variants. MAb-X and mAb-Y are two approved IgG1 …

Monoclonal antibody (mAb)-based therapeutics are playing an increasingly important role in
the treatment or prevention of many important diseases such as cancers, autoimmune …

Mass spectrometry (MS) is one of the key analytical techniques to detect and to identify
primary sequence differences, to assess similarity and to evaluate batch variability of …

The development of therapeutic antibodies has grown over the last several years. Most of
the recombinant monoclonal antibodies (mAbs) produced by mammalian cells are …