Sleep quality in efavirenz-treated Chinese HIV patients–comparing between GT and GG genotype of CYP2B6-516 G/T polymorphisms
Seventy-two adult Chinese HIV-positive treatment-naïve patients were recruited in a study to
evaluate prospectively the associations between CYP2B6 516 G/T polymorphisms and …
evaluate prospectively the associations between CYP2B6 516 G/T polymorphisms and …
[HTML][HTML] The effect of rifampicin-based antitubercular therapy and cytochrome P450 2B6 genotype on efavirenz mid-dosing interval concentrations in a South African …
Background Rifampicin may decrease efavirenz concentrations by inducing expression of
cytochrome P450 isoenzyme 2B6 (CYP2B6), which metabolises efavirenz. The CYP2B6 …
cytochrome P450 isoenzyme 2B6 (CYP2B6), which metabolises efavirenz. The CYP2B6 …
Correlation of CYP2B6-516G> T polymorphism with plasma efavirenz concentration and depression in HIV-infected adults in Northern Thailand
L Aurpibul, N Chotirosniramit… - Current HIV …, 2012 - ingentaconnect.com
Background: Single nucleotide polymorphism of the hepatic cytochrome P450 isoenzyme
2B6 (CYP2B6) gene is a cause of variation in plasma efavirenz (EFV) concentrations. We …
2B6 (CYP2B6) gene is a cause of variation in plasma efavirenz (EFV) concentrations. We …
Impact of efavirenz pharmacokinetics and pharmacogenomics on neuropsychological performance in older HIV-infected patients
U Sandkovsky, AT Podany, CV Fletcher… - Journal of …, 2016 - academic.oup.com
Background Pharmacokinetics (PK) and pharmacodynamics of efavirenz and its 8-hydroxy
metabolite (8-OH-efavirenz) have not been robustly evaluated in older HIV-infected persons …
metabolite (8-OH-efavirenz) have not been robustly evaluated in older HIV-infected persons …
A pharmacogenomic prospective randomized controlled trial of CYP2B6 polymorphisms and efavirenz dose adjustment among HIV-infected Thai patients: a pilot …
P Damronglerd, C Sukasem… - Pharmacogenomics …, 2015 - Taylor & Francis
Objective We aimed at comparing clinical/immunological outcomes in human
immunodeficiency virus (HIV)-infected patients who were treated with CYP2B6-guided and …
immunodeficiency virus (HIV)-infected patients who were treated with CYP2B6-guided and …
Meta-analysis of the associations of CYP2B6-516G> T polymorphisms with efavirenz-induced central nervous system side effects and virological outcome in HIV …
L Cheng, Y Wang, X Li, W Feng, B Weng… - The …, 2020 - nature.com
Clinical data on the relationships of cytochrome P450 (CYP2) B6 516G> T polymorphisms
with efavirenz-induced central nervous system (CNS) side effects and virological response …
with efavirenz-induced central nervous system (CNS) side effects and virological response …
Sleep and neuropsychological performance in HIV+ subjects on efavirenz-based therapy and response to switch in therapy
CM Shikuma, L Kohorn, R Paul, DC Chow… - HIV clinical …, 2018 - Taylor & Francis
The antiretroviral drug efavirenz (EFV) has been linked to disordered sleep and cognitive
abnormalities. We examined sleep and cognitive function and subsequent changes …
abnormalities. We examined sleep and cognitive function and subsequent changes …
CYP2B6 Genetic Polymorphisms, Depression, and Viral Suppression in Adults Living with HIV Initiating Efavirenz-Containing Antiretroviral Therapy Regimens in …
Single-nucleotide polymorphisms (SNPs) in CYP2B6 have been shown to predict variation
in plasma efavirenz concentrations, but associations between these SNPs and efavirenz …
in plasma efavirenz concentrations, but associations between these SNPs and efavirenz …
[PDF][PDF] Anxiety, depression and sleep disturbances in HIV+ patients chronically treated with an efavirenz-based regimen
BM Celesia, SA Sofia, L Rapisarda… - Infect Dis Trop …, 2017 - infectiousjournal.com
Objective: Sleep disturbances have frequently been observed in HIV+ patients. Low sleep
quality has also been associated with the use of Efavirenz (EFV). Anxiety and depression …
quality has also been associated with the use of Efavirenz (EFV). Anxiety and depression …
Secondary metabolism pathway polymorphisms and plasma efavirenz concentrations in HIV-infected adults with CYP2B6 slow metabolizer genotypes
DW Haas, A Kwara, DM Richardson… - Journal of …, 2014 - academic.oup.com
Objectives Efavirenz is widely prescribed for HIV-1 infection, and CYP2B6 polymorphisms
516G→ T and 983T→ C define efavirenz slow metabolizer genotypes. To identify genetic …
516G→ T and 983T→ C define efavirenz slow metabolizer genotypes. To identify genetic …