Parkinson's disease (PD) is a common neurodegenerative condition marked by the
degeneration of dopaminergic neurons and the amassing of α-synuclein protein in Lewy …

Introduction: Parkinson disease (PD) is the most common neurodegenerative movement
disorder. Currently only symptomatic treatments exist for PD, and so the search for potential …

One of the main pathways of lysosomal proteolysis is chaperone-mediated autophagy
(CMA), which represents a selective mechanism for the degradation of specific soluble …

The progressive aging of the population and the fact that Parkinson's disease currently does
not have any curative treatment turn out to be essential issues in the following years, where …

Converging evidence from genetic, pathological and experimental studies have increasingly
suggested an important role for autophagy impairment in Parkinson's Disease (PD). Genetic …

Cellular quality control systems have gained much attention in recent decades. Among
these, autophagy is a natural self-preservation mechanism that continuously eliminates toxic …

Macroautophagy, an evolutionary conserved catabolic process in the eukaryotic cell,
regulates cellular homeostasis and plays a decisive role in self-engulfing proteins, protein …

Parkinson's disease (PD) is the second most prevalent neurodegenerative disease.
Epidemiological projections for the global incidence of PD indicate that the number of …

Chaperone-mediated autophagy (CMA) is the selective degradation process of intracellular
components by lysosomes, which is required for the degradation of aggregate-prone …

Autophagy is an essential catabolic mechanism that delivers misfolded proteins and
damaged organelles to the lysosome for degradation. Autophagy pathways include …