Cerebral energetics and spiking frequency: the neurophysiological basis of fMRI

AJ Smith, H Blumenfeld, KL Behar… - Proceedings of the …, 2002 - National Acad Sciences
Functional MRI (fMRI) is widely assumed to measure neuronal activity, but no satisfactory
mechanism for this linkage has been identified. Here we derived the changes in the …

Total neuroenergetics support localized brain activity: implications for the interpretation of fMRI

F Hyder, DL Rothman… - Proceedings of the …, 2002 - National Acad Sciences
In α-chloralose-anesthetized rats, changes in the blood oxygenation level-dependent
(BOLD) functional MRI (fMRI) signal (ΔS/S), and the relative spiking frequency of a neuronal …

Biophysical basis of brain activity: implications for neuroimaging

RG Shulman, F Hyder, DL Rothman - Quarterly reviews of biophysics, 2002 - cambridge.org
Introduction 2883. Relationship between neuroenergetics and neurotransmitter flux 2944. A
model of coupling between neuroenergetics and neurotransmission 2965. Relationship …

Energetics of neuronal signaling and fMRI activity

NJG Maandag, D Coman… - Proceedings of the …, 2007 - National Acad Sciences
Energetics of resting and evoked fMRI signals were related to localized ensemble firing
rates (ν) measured by electrophysiology in rats. Two different unstimulated, or baseline …

Energetic basis of brain activity: implications for neuroimaging

RG Shulman, DL Rothman, KL Behar, F Hyder - Trends in neurosciences, 2004 - cell.com
The complex activities of the brain need not distract us from the certainty that it uses energy
and performs work very efficiently. The human brain, which claims∼ 2% of our body mass, is …

Baseline blood oxygenation modulates response amplitude: physiologic basis for intersubject variations in functional MRI signals

H Lu, C Zhao, Y Ge… - Magnetic Resonance in …, 2008 - Wiley Online Library
Abstract Although BOLD functional MRI (fMRI) provides a useful tool for probing neuronal
activities, large intersubject variations in signal amplitude are commonly observed …

The neural basis of functional brain imaging signals

D Attwell, C Iadecola - Trends in neurosciences, 2002 - cell.com
The haemodynamic responses to neural activity that underlie the blood-oxygen-level-
dependent (BOLD) signal used in functional magnetic resonance imaging (fMRI) of the brain …

Neural basis of global resting-state fMRI activity

ML Schölvinck, A Maier, FQ Ye… - Proceedings of the …, 2010 - National Acad Sciences
Functional MRI (fMRI) has uncovered widespread hemodynamic fluctuations in the brain
during rest. Recent electroencephalographic work in humans and microelectrode recordings …

What does fMRI tell us about neuronal activity?

DJ Heeger, D Ress - Nature reviews neuroscience, 2002 - nature.com
In recent years, cognitive neuroscientists have taken great advantage of functional magnetic
resonance imaging (fMRI) as a non-invasive method of measuring neuronal activity in the …

Biophysical and physiological origins of blood oxygenation level-dependent fMRI signals

SG Kim, S Ogawa - Journal of Cerebral Blood Flow & …, 2012 - journals.sagepub.com
After its discovery in 1990, blood oxygenation level-dependent (BOLD) contrast in functional
magnetic resonance imaging (fMRI) has been widely used to map brain activation in …