The accumulation of non-enzymatic modifications on both DNA and protein molecules under
the attack of reactive oxygen species (ROS), is one of the most possible factors responsible …

The scope of the current paper is to review existing and potential applications of proteomic
analysis to aging research. The focus will lie on the unique opportunities of high-throughput …

Functional decline of tissues in aged animals is a result of cellular aging. Though any
process of somatic cell aging basically depends on genomic instructions, phenotypes of …

Aging is characterized by changes in a variety of cellular phenotypes, which in turn are
caused by alterations in the concentrations, compositions, and interactions of cellular …

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Basal levels of oxidants are indispensible for redox signaling to produce adaptive cellular
responses such as vitagenes linked to cell survival; however, at higher levels, they are …

Aging is a gradual, complex process in which cells, tissues, organs, and the whole organism
itself deteriorate in a progressive and irreversible manner that, in the majority of cases …

The first gerontological studies using two-dimensional gel electrophoresis (2DGE) were
frustating since it was very difficult, when not impossible, to identify the proteins for which an …

Based on demographic trends, the societies in many developed countries are facing an
increasing number and proportion of people over the age of 65. The raise in elderly …

It is well established that the risk to develop neurodegenerative disorders increases with
chronological aging. Accumulating studies contributed to characterize the age-dependent …