Boron inhibits the proliferating cell nuclear antigen index, molybdenum containing proteins and ameliorates oxidative stress in hepatocellular carcinoma

H Zafar, S Ali - Archives of biochemistry and biophysics, 2013 - Elsevier
Hepatocellular carcinoma (HCC) is a common malignancy and the main cause of mortality
in patients with chronic liver diseases. This study reports the inhibitory effect of boron on …

Boric acid exert anti-cancer effect in poorly differentiated hepatocellular carcinoma cells via inhibition of AKT signaling pathway

E Kahraman, E Göker - Journal of Trace Elements in Medicine and Biology, 2022 - Elsevier
Background The possible anti-cancer properties of boron, a trace element for humans, have
been demonstrated in various experimental and epidemiological studies, although the …

Boron ameliorates fulminant hepatic failure by counteracting the changes associated with the oxidative stress

S Pawa, S Ali - Chemico-biological interactions, 2006 - Elsevier
Boron has well-defined biological effects and may be of therapeutic benefit. In the current
paper, the effect of boron in the form of borax was tested in experimental animal model of …

Therapeutic effects of newly synthesized boron compounds (BGM and BGD) on hepatocellular carcinoma

MK Gündüz, M Bolat, G Kaymak, D Berikten… - … Trace Element Research, 2022 - Springer
Boron has an important potential for facilitating biological activity and for use in
pharmaceutical drug design. Boron glycine monoester (BGM) and boron glycine diester …

Effects of boron on structure and antioxidative activities of spleen in rats

Q Hu, S Li, E Qiao, Z Tang, E Jin, G Jin, Y Gu - Biological trace element …, 2014 - Springer
In order to determine the relationship between boron and development of the spleen,
especially in the promoting biological effects, we examined the effects of different levels of …

Brain boron level, DNA content, and myeloperoxidase activity of metformin-treated rats in diabetes and prostate cancer model

AB Ozel, E Dagsuyu, PK Aydın, I Bugan… - … Trace Element Research, 2022 - Springer
In this study, the effect of metformin on boron levels and oxidative brain damage in rats due
to diabetes and prostate cancer was investigated for the first time. Myeloperoxidase (MPO) …

Hepatoprotective effect of boldine against diethylnitrosamine‐induced hepatocarcinogenesis in wistar rats

N Subramaniam, P Kannan, AK… - … of biochemical and …, 2019 - Wiley Online Library
Discovering the utmost effective and targeted chemotherapy for hepatocellular carcinoma is
still a significant challenge. In the present study, diethylnitrosamine was used as a liver …

Antimutagenic activity and in vitro anticancer effects of bamboo salt on HepG2 human hepatoma cells

X Zhao, J Ju, HM Kim, KY Park - Journal of Environmental …, 2013 - dl.begellhouse.com
Bamboo salt is a traditional Korean baked solar salt processed by packing the solar salt in
bamboo joint cases and heating it several times to high temperatures. The antimutagenic …

Gene expression alterations of human liver cancer cells following borax exposure

L Wu, Y Wei, WB Zhou, YS Zhang… - Oncology …, 2019 - spandidos-publications.com
Borax is a boron compound that is becoming widely recognized for its biological effects,
including lipid peroxidation, cytotoxicity, genotoxicity, antioxidant activity and potential …

[PDF][PDF] Borax-induced apoptosis in HepG2 cells involves p53, Bcl-2, and Bax

Y Wei, FJ Yuan, WB Zhou, L Wu, L Chen, JJ Wang… - Genet Mol …, 2016 - funpecrp.com.br
Borax, a boron compound and a salt of boric acid, is known to inhibit the growth of tumor
cells. HepG2 cells have been shown to be clearly susceptible to the anti-proliferative effects …