Methionine adenosyltransferase (MAT) is involved in folate-mediated one-carbon
metabolism, which is essential for preimplantation embryos in terms of both short-term …

Abstract Methionine adenosyltransferase II (MAT2A) is essential to the synthesis of S-
adenosylmethionine, a major methyl donor, from L-methionine and ATP. Upon fertilization …

The roles of methionine metabolism in bovine preimplantation embryo development were
investigated by using ethionine, an antimetabolite of methionine. In vitro produced bovine …

Objectives Early pregnancy loss is a major clinical concern in animal and human
reproduction, which is largely influenced by embryo implantation. The importance of …

Maternal nutrition exclusively during the periconceptional period can induce remarkable
effects on both oocyte maturation and early embryo development, which in turn can have …

Aim: There is a growing concern about the potential adverse effects of high dose folic acid
(FA) supplementation before and during pregnancy. FA metabolism generates S-adenosyl …

The methionine adenosyltransferase 2β gene (Mat2b) encodes for the regulatory subunit of
methionine adenosyltransferase (MAT), which catalyzes the biosynthesis of S …

To investigate a possible mechanism for inducing epigenetic defects in the preimplantation
embryo, a human embryonic stem cell model was developed, and gene expression of the …

One-carbon metabolism is a key metabolic network that integrates nutritional signals with
embryonic development. However, the response of one-carbon metabolism to methionine …

It has been reported that N6-methyladenosine (m6A) methyltransferase-like 3 (METTL3)
plays an important role in zygote genome activation during embryonic development, but the …