Neuro-immune interactions contribute to the pathogenesis of neuropathic pain due to
peripheral nerve injury. A large body of preclinical evidence supports the idea that the …

In a large proportion of individuals nervous system damage may lead to a debilitating
chronic neuropathic pain. Such pain may now be considered a neuro-immune disorder …

The nociceptive nervous system and the immune system serve to defend and alarm the host
of imminent or actual damage. However, persistent or recurring exposure of neurons to …

Mounting evidence indicates that disruptions in bidirectional communication pathways
between the central nervous system (CNS) and peripheral immune system underlie the …

One area that has emerged as a promising therapeutic target for the treatment and
prevention of chronic pain and opioid tolerance/hyperalgesia is the modulation of the central …

Neuroinflammation is a complex process involving both the peripheral circulation and the
Central Nervous System (CNS) and is considered to underlie many CNS disorders including …

Recent evidence implicates an adaptive immune response in the central nervous system
(CNS) mechanisms of neuropathic pain. This review identifies how neuropathic pain alters …

Pain is an unpleasant sensation associated with injury, inflammation, and infection. It has
been demonstrated that communication between immune cells and neurons plays a vital …

Background Acute pain is a warning mechanism that exists to prevent tissue damage,
however pain can outlast its protective purpose and persist beyond injury, becoming …

Chronic pain can occur after peripheral nerve injury, infection, or inflammation. Under such
neuropathic pain conditions, sensory processing in the affected body region becomes …