Aim: Genipin, a metabolite of geniposide, is reported to stimulate the insertion of multidrug
resistance protein 2 (Mrp2) in the bile canalicular membrane, and to cause choleresis by …

Aim: Genipin is reported to stimulate the insertion of multidrug resistance protein 2 (Mrp2) in
the bile canalicular membrane, thereby causing choleresis by the increased the biliary …

Abstract Inchin‐ko‐to (ICKT), an herbal medicine, and its ingredients exert potent choleretic
effects by a “bile acid‐independent” mechanism. The current study was designed to …

The mechanisms involved in spironolactone (SL, 200μmol/kg body weight, 3 days ip)-
induced choleresis were explored in vivo by evaluating bile salt export pump (Bsep) …

The effect of kepone on the biliary excretion of [14C] imipramine (IMP) was studied using
isolated perfused rat liver preparations obtained from control and kepone-pretreated …

The effect of spironolactone (SL) administration on 17α-ethynylestradiol (EE)-induced
cholestasis was studied, with emphasis on expression and activity of Mrps. Adult male …

Multidrug resistance protein 2 (Mrp2) is an important transporter for biliary excretion of
organic anions, and is reported to be up-regulated by dexamethasone. In the present study …

Purpose. This study assesses the impact of rat multidrug resistance-associated protein 2
(Mrp2) on the biliary excretion and oral absorption of furosemide, probenecid, and …

The insecticides mirex and chlordecone have previously been found to suppress the biliary
excretion of a wide variety of compounds. In the present studies, the effects of mirex …

The aim of this study is to investigate how the semisynthetic bile acid; 3a, 7a-dihydroxy-12-
keto-5b-cholanate, also known as 12-monoketocholic acid (MKC) influences the ileal …