Bright ideas for chemical biology

LD Lavis, RT Raines - ACS chemical biology, 2008 - ACS Publications
Small-molecule fluorescent probes embody an essential facet of chemical biology. Although
numerous compounds are known, the ensemble of fluorescent probes is based on a modest …

Bright building blocks for chemical biology

LD Lavis, RT Raines - ACS chemical biology, 2014 - ACS Publications
Small-molecule fluorophores manifest the ability of chemistry to solve problems in biology.
As we noted in a previous review (Lavis, LD; Raines, RT ACS Chem. Biol. 2008, 3, 142 …

The chemistry of small-molecule fluorogenic probes

JB Grimm, LM Heckman, LD Lavis - Progress in molecular biology and …, 2013 - Elsevier
Chemical fluorophores find wide use in biology to detect and visualize different phenomena.
A key advantage of small-molecule dyes is the ability to construct compounds where …

Rational design of small molecule fluorescent probes for biological applications

JV Jun, DM Chenoweth, EJ Petersson - Organic & biomolecular …, 2020 - pubs.rsc.org
Fluorescent small molecules are powerful tools for visualizing biological events, embodying
an essential facet of chemical biology. Since the discovery of the first organic fluorophore …

Lessons in organic fluorescent probe discovery

SB Wagh, VA Maslivetc, JJ La Clair… - ChemBioChem, 2021 - Wiley Online Library
Fluorescent probes have gained profound use in biotechnology, drug discovery, medical
diagnostics, molecular and cell biology. The development of methods for the translation of …

Fluorogenic label for biomolecular imaging

LD Lavis, TY Chao, RT Raines - ACS chemical biology, 2006 - ACS Publications
Traditional small-molecule fluorophores are always fluorescent. This attribute can obscure
valuable information in biological experiments. Here, we report on a versatile “latent” …

Reaction-based small-molecule fluorescent probes for chemoselective bioimaging

J Chan, SC Dodani, CJ Chang - Nature chemistry, 2012 - nature.com
The dynamic chemical diversity of elements, ions and molecules that form the basis of life
offers both a challenge and an opportunity for study. Small-molecule fluorescent probes can …

Fluorescent probes for sensing and imaging

T Ueno, T Nagano - Nature methods, 2011 - nature.com
Fluorescent probes for sensing and imaging | Nature Methods Skip to main content Thank you
for visiting nature.com. You are using a browser version with limited support for CSS. To obtain …

Fluorescent probes for the detection of disease-associated biomarkers

WT Dou, HH Han, AC Sedgwick, GB Zhu, Y Zang… - Science Bulletin, 2022 - Elsevier
Fluorescent probes have emerged as indispensable chemical tools to the field of chemical
biology and medicine. The ability to detect intracellular species and monitor physiological …

Advances in the chemistry of small molecule fluorescent probes

LM Wysocki, LD Lavis - Current opinion in chemical biology, 2011 - Elsevier
Small molecule fluorophores are essential tools for chemical biology. A benefit of synthetic
dyes is the ability to employ chemical approaches to control the properties and direct the …