Cardiac fibrosis are central to various cardiovascular diseases. Research on the
mechanisms and therapeutic targets for cardiac fibrosis has advanced greatly in recent …

Fibrosis is an accumulation of proteins including collagen in the extracellular space, which
has previously been considered as irreversible damage in various cardiovascular diseases …

Cardiac fibrosis is defined as the imbalance of extracellular matrix (ECM) production and
degradation, thus contributing to cardiac dysfunction in many cardiac pathophysiologic …

Heart failure is a leading cause of mortality and hospitalization worldwide. Cardiac fibrosis,
resulting from the excessive deposition of collagen fibers, is a common feature across the …

Fibrosis, characterized by an excessive accumulation of extracellular matrix, has long been
seen as an adaptive process that contributes to tissue healing and regeneration. More …

Cardiovascular disease is a leading cause of mortality in the world and is exacerbated by
the presence of cardiac fibrosis, defined by the accumulation of noncontractile extracellular …

Cardiac fibrosis is characterized by net accumulation of extracellular matrix proteins in the
cardiac interstitium, and contributes to both systolic and diastolic dysfunction in many …

Fibrosis is a pivotal player in heart failure development and progression. Measurements of
(markers of) fibrosis in tissue and blood may help to diagnose and risk stratify patients with …

Cardiac fibrosis is characterized by the deposition of extracellular matrix proteins in the
spaces between cardiomyocytes following both acute and chronic tissue damage events …

Cardiac fibrosis is characteristic of the end stage in nearly all forms of heart disease.
Accumulation of extracellular matrix in the myocardium leads to increased risk of arrhythmia …