Repositioning of the global epicentre of non-optimal cholesterol

Nature, 2020 - nature.com
High blood cholesterol is typically considered a feature of wealthy western countries,.
However, dietary and behavioural determinants of blood cholesterol are changing rapidly …

Repositioning of the global epicentre of non-optimal cholesterol

C Taddei, B Zhou, H Bixby, R Carrillo-Larco… - Nature, 2020 - repository.mdx.ac.uk
High blood cholesterol is typically considered a feature of wealthy western countries1, 2.
However, dietary and behavioural determinants of blood cholesterol are changing rapidly …

A new era for quantifying HDL and cardiovascular risk?

JW Heinecke - Nature medicine, 2012 - nature.com
BETWEEN BEDSIDE AND BENCH depleted of the atherogenic lipoproteins LDL and VLDL,
which deliver cholesterol to macrophage foam cells5. They showed that human serum …

National, regional, and global trends in serum total cholesterol since 1980: systematic analysis of health examination surveys and epidemiological studies with 321 …

F Farzadfar, MM Finucane, G Danaei, PM Pelizzari… - The Lancet, 2011 - thelancet.com
Background Data for trends in serum cholesterol are needed to understand the effects of its
dietary, lifestyle, and pharmacological determinants; set intervention priorities; and evaluate …

National trends in total cholesterol obscure heterogeneous changes in HDL and non-HDL cholesterol and total-to-HDL cholesterol ratio: a pooled analysis of 458 …

International Journal of Epidemiology, 2020 - academic.oup.com
Background Although high-density lipoprotein (HDL) and non-HDL cholesterol have
opposite associations with coronary heart disease, multi-country reports of lipid trends only …

Total and high-density lipoprotein cholesterol in adults: United States, 2015–2018

MD Carroll, CD Fryar - 2020 - stacks.cdc.gov
Data from the National Health and Nutrition Examination Survey• During 2015–2018, 11.4%
of adults had high total cholesterol, and prevalence was similar by race and Hispanic origin.• …

LDL-cholesterol concentrations: a genome-wide association study

MS Sandhu, DM Waterworth, SL Debenham… - The Lancet, 2008 - thelancet.com
Background LDL cholesterol has a causal role in the development of cardiovascular
disease. Improved understanding of the biological mechanisms that underlie the metabolism …

Is it time to revise the HDL cholesterol hypothesis?

DJ Rader, AR Tall - Nature medicine, 2012 - nature.com
Formation of plaques in artery walls, or atherogenesis, is known to lead to cardiovascular
disease risk and heart disease. Low-density lipoproteins (LDLs), which deliver cholesterol to …

Application of non-HDL cholesterol for population-based cardiovascular risk stratification: results from the Multinational Cardiovascular Risk Consortium

FJ Brunner, C Waldeyer, F Ojeda, V Salomaa, F Kee… - The lancet, 2019 - thelancet.com
Background The relevance of blood lipid concentrations to long-term incidence of
cardiovascular disease and the relevance of lipid-lowering therapy for cardiovascular …

The power of genetic diversity in genome-wide association studies of lipids

SE Graham, SL Clarke, KHH Wu, S Kanoni, GJM Zajac… - Nature, 2021 - nature.com
Increased blood lipid levels are heritable risk factors of cardiovascular disease with varied
prevalence worldwide owing to different dietary patterns and medication use. Despite …