Significance: Mitochondria play a critical role in the physiology of the heart by controlling
cardiac metabolism, function, and remodeling. Accumulation of fragmented and damaged …

Mitochondria are dynamic organelles that alter their morphology through fission
(fragmentation) and fusion (elongation). These morphological changes correlate highly with …

Mitochondria are no longer considered to be solely the static powerhouses of the cell. While
they are undoubtedly essential to sustaining life and meeting the energy requirements of the …

The past decade has witnessed a number of exciting developments in the field of
mitochondrial dynamics–a phenomenon in which changes in mitochondrial shape and …

Mitochondria are essential organelles that produce the cellular energy source, ATP.
Dysfunctional mitochondria are involved in the pathophysiology of heart disease, which is …

Mitochondria represent approximately one-third of the mass of the heart and play a critical
role in maintaining cellular function-however, they are also a potent source of free radicals …

The highly regulated processes of mitochondrial fusion (joining), fission (division) and
trafficking, collectively called mitochondrial dynamics, determine cell-type specific …

Cardiac hypertrophy is often initiated as an adaptive response to haemodynamic stress or
myocardial injury, and allows the heart to meet an increased demand for oxygen. Although …

Over the past decade, mitochondria have emerged as critical integrators of energy
production, generation of reactive oxygen species (ROS), multiple cell death, and signaling …

Mitochondrial fragmentation frequently occurs in chronic pathological conditions as seen in
various human diseases. In fact, abnormal mitochondrial morphology and mitochondrial …