We previously showed that ADAM17 mediates high glucose-induced matrix production by
kidney mesangial cells. ADAM17 expression is increased in diabetic kidneys, suggesting …

It is known that the renin-angiotensin system plays a major role in the pathophysiology of
cardiovascular disease and renal injury. Within the renin-angiotensin system, angiotensin …

A disintegrin and metalloproteinase (ADAM) 17 sheds growth factors from the cell
membrane, including epidermal growth factor receptor (EGFR) ligand transforming growth …

ADAM19, an enzyme from the ADAM (ad isintegrin and metalloproteinase) family, is
involved in various cell–cell and cell–matrix interactions. It can cleave epidermal growth …

Background The importance of the Notch signaling in the development of glomerular
diseases has been recently described. Therefore we analyzed in podocytes the expression …

Glomerular matrix accumulation is the hallmark of diabetic nephropathy. The
metalloprotease ADAM17 mediates high glucose (HG)-induced matrix production by kidney …

Background. Interstitial fibrosis and tubular atrophy (IF/TA) is an important cause of renal
function loss and ischaemia–reperfusion (I/R) injury is considered to play an important role …

ADAM17 is a disintegrin and metalloproteinase capable of cleaving the ectodomains of a
diverse variety of molecules including TNF-α, TGF-α, L-selectin, and ACE2. We have …

Matrix protein accumulation is a prominent feature of diabetic nephropathy that contributes
to renal fibrosis and decline in renal function. The pathogenic mechanisms of matrix …

Background The disintegrin and metalloenzyme ADAM17 participates in numerous
inflammatory and proliferative diseases, and its pathophysiological role was implicated in …