Cyclooxygenase-2 (COX-2) is a key enzyme in the production of prostaglandins and
thromboxanes from free arachidonic acid. Increasing evidence suggests that COX-2 plays a …

Abstract Cyclooxygenase 2 (COX-2) overexpression is found in a wide variety of human
cancers and is linked to all stages of tumorigenesis. Elevated tumor COX-2 expression is …

Cyclooxygenase (Cox)-2 plays an important role in cell proliferation, carcinogenesis and
tumor growth, in part through the synthesis of prostaglandin E2 (PGE2) as well as through …

Multiple lines of evidence suggest that cyclooxygenase-2 (COX-2) upregulation is an early
event in the development of non-small-cell lung cancer. Preclinical data indicate tumors with …

Abstract Background Cyclooxygenase (COX)-2 has been implicated in tumour progression,
angiogenesis and metastasis in non-small cell lung cancer (NSCLC). We speculated that …

Preclinical studies suggest that cyclooxygenase (COX)-2 may be involved in the molecular
pathogenesis of some types of lung cancer. Most of the available studies point to its …

Background Vascular endothelial growth factor (VEGF) expression is up-regulated via a
cyclooxygenase-2 (COX-2)-dependent mechanism in non-small cell lung cancer (NSCLC) …

Increased expression of cyclooxygenase-2 (COX-2) expression has been observed in
several human tumor types and in selected animal and cell culture models of …

The epidermal growth factor receptor (EGFR) is part of a family of plasma membrane
receptor tyrosine kinases that control many important cellular functions, from growth and …

Abstract Cyclooxygenase (COX)-2, the inducible isoform of prostaglandin H synthase, has
been implicated in the progression of human lung adenocarcinoma. However, the …