Previous studies have suggested that quinazolinone derivatives are potent apoptosis-
inducing agents in various cancer cell lines. In the present study, we have investigated …

Spiroquinazolinone compounds have been considered as a new series of potent apoptosis-
inducing agents. In this study, anti-proliferative and apoptotic effects of the derivatives from …

We synthesised a new series of sulphonamide-bearing quinazolinone derivatives 5-18 and
evaluated their in vitro cytotoxicity in various cancer cell lines (A549, HepG-2, LoVo and …

Aim: Novel quinazolinone and triazinoquinazolinone derivatives were designed and
synthesized as apoptotic inducers. Methodology/results: Most of the synthesized compounds …

A series of new 4 (3H)-quinazolinones were synthesized and evaluated for their cytotoxic
activity against a set of human cancer cell lines MDA-MB-231 and MCF-7 (breast), HCT-116 …

Background: Searching for new cytotoxic agents with apoptosis induction may represent a
viable strategy for cancer treatment to overcome the increased resistance to available …

In order to investigate for a new effective and safe anticancer drug, we synthesized a novel
series of quinazoline containing biologically active substituted-sulfonamide moiety at 3 …

The current study investigated the cytotoxic effect of 3-(5-chloro-2-hydroxybenzylideneamino
)-2-(5-chloro-2-hydroxyphenyl)-2, 3-dihydroquinazolin-41 (H)-one (A) and 3-(5-nitro-2 …

We have synthesized a novel quinazolinone chalcone derivative (QC) and first time reported
its in-vitro and in-vivo anticancer potential. It inhibited the cell proliferation of different cancer …

Targeting Survivin, as an inhibitor of apoptosis and a regulator of cell division, has become a
worldwide controversial issue. Piperine as a pungent alkaloid has been identified as the …