Introduction MAPT H1 haplotype is implicated as a risk factor for neurodegenerative
diseases including Alzheimer's disease (AD). Methods Using Alzheimer's Disease Genetics …

Introduction MAPT encodes for tau, the predominant component of neurofibrillary tangles
that are neuropathological hallmarks of Alzheimer's disease (AD). Genetic association of …

Objective: In African Americans, we sought to systematically identify coding Alzheimer
disease (AD) risk variants at the previously reported AD genome-wide association study …

Abstract Background Late onset Alzheimer's disease (LOAD) is a common sporadic form of
the illness, affecting individuals above the age of 65 yrs. A prominent hypothesis for the …

Cerebrospinal fluid (CSF) tau, tau phosphorylated at threonine 181 (ptau), and Aβ 42 are
established biomarkers for Alzheimer's disease (AD) and have been used as quantitative …

Published studies revealed that the microtubule-associated protein tau (MAPT) gene
polymorphisms increased Alzheimer's disease (AD) risk; the associations of 4 single …

Abstract Introduction Genetic loci for Alzheimer's disease (AD) have been identified in whites
of European ancestry, but the genetic architecture of AD among other populations is less …

Background Genome-wide association studies (GWAS) have indicated moderate genetic
overlap between Alzheimer's disease (AD) and related dementias (ADRD), Parkinson's …

Background Alzheimer's disease (AD) is an incurable neurodegenerative disease currently
affecting 1.75% of the US population, with projected growth to 3.46% by 2050. Identifying …

Genome-wide association studies (GWASs) have reported numerous associations between
risk variants and Alzheimer's disease (AD). However, these associations do not necessarily …