Internalization by cells of radiolabeled protein ligands bound to the cell surface is frequently
analyzed by extraction of the cells with low pH buffers. This treatment supposedly strips the …

MEI8Oand threeof the otherradiolabelswere also tested with this anbbody-targetcell
combinadonfor comparison. Results: Iodineconjugatedto antibOdieSby …

In order to obtain rapid blood clearance of circulating antibodies (Ab) at a desired time, cross-
linking reagents such as second Ab are often employed. Such reagents will generally bind …

The effect of using a “residualizing” iodine radiolabel, dilactitol-iodotyramine, for
radioimmunolocalization of antibodies to tumors was investigated. This tracer is designed to …

Our results demonstrate that upon incubation of 125I-3G5 (a monoclonal IgM against a
membrane ganglioside antigen on RINm5F cells) with rat insulinoma RINm5F cell …

[en] The hepatic dehalogenation of radiolabeled monoclonal antibodies (MoAb) has been
observed and reported repeatedly. The reason for this phenomenon has not been examined …

Monoclonal antibodies (mAbs) labeled with α-emitting radionuclides such as 211At, 212Bi,
213Bi, and 212Pb (which decays by β-emission to its α-emitting daughter, 212Bi) are being …

This study addresses the impact of background activity on the use of
radioimmunoconjugates for radioimmunodiagnosis and radioimmunotherapy. Since the liver …

Background. Previous experiments indicated that most antibodies binding to cell surface
antigens are internalized gradually and degraded within lysosomes, with a half‐life of …

Monoclonal antibodies are assuming increasing importance in experimental and clinical
medicine. Generally, tissue biodistribution studies in animals precede human studies. To …