Background Accelerated gastric emptying (GE) is a trait seen in obesity. Mutations in the
hypothalamic leptin‐melanocortin 4 receptor (Leptin‐MC4R) pathway have been associated …

Methods: This is a retrospective cohort study from adult participants who have undergone
genetic testing and phenotype classification for obesity. Analysis was divided by 1) patients …

Abstract Melanocortin-4 receptor gene (MC4R) variants are associated with obesity and
binge eating disorder (BED), whereas the more prevalent proopiomelanocortin (POMC) and …

Dear Sir: We read with great interest the recent paper by Sobhani and Bado et al. 1, 2 who
demonstrated that vagal stimulation rapidly increases leptin secretion in the human …

Congenital leptin deficiency, a rare genetic disorder due to a homozygous mutation in the
leptin gene (LEP), is accompanied by extreme obesity and hyperphagia. A number of …

Mutations leading to a reduced or loss of function in genes of the leptin-melanocortin system
confer a risk for monogenic forms of obesity. Yet, gain of function variants in the …

THE PREVALENCE OF OBESITY and its secondary health risks have dramatically
increased over the last two decades (17), and despite accelerated research and drug …

BACKGROUND: Although esophageal hypomotility is prevalent in obese patients, its cause
remains unknown. Leptin, a hormone derived from adipose tissue, may be involved in this …

Background Leptin is well known as a satiety hormone to regulate energy balance by
inhibiting hunger. However, an inability for leptin to act normally occurs in obesity, a …

Background: Melanocortin-4 receptor gene (MC4R) variants, common in monogenic obesity,
are associated with binge eating disorder (BED), which in turn may be associated with …