The c-fos proto-oncogene provides a good system to study the processes underlying
messenger RNA degradation. After growth factor stimulation of susceptible cells, the c-fos …

Rapid degradation of c-fos proto-oncogene mRNA is crucial for transient c-fos gene
expression. Experiments were performed to investigate the cellular mechanisms responsible …

The c-fos proto-oncogene transcript is one of the most labile mammalian mRNAs known.
Rapid degradation of c-fos mRNA is mediated by both the c-fos protein-coding region and …

The proto-oncogene products c-Fos and c-Jun heterodimerize through their leucine zippers
to form the AP-1 transcription factor. The transcriptional activity of the heterodimer is …

THE proto-oncogene c-fos is the cellular homologue of v-fos originally isolated from murine
osteosarcoma1. Fos protein is a major component of the AP-1 transcription factor complex …

The mechanisms by which c-fos mRNA is targeted for decay have been examined. Rapid
removal of the poly (A) tail occurs before the transcribed portion of the c-fos message is …

An AU-rich sequence present within the 3′ untranslated region has been shown to mark
some short-lived mRNAs for rapid degradation. We demonstrate by label transfer and gel …

AU-rich elements (AREs) in the 3′ untranslated regions of several cytokine and oncogene
mRNAs have been shown to function as signals for rapid mRNA degradation, and it is …

PROTO-ONCOGENE fos encodes a nuclear phosphoprotein of 380 amino acids that can
modulate the transcription of other genes either by transactivation or by transrepression1-7 …

WE have shown that, when injected into Xenopus oocytes, poly (A) free globin messenger
RNA is translated for a short period of time and then rapidly degraded1–3, while, under the …