High-grade prostatic intraepithelial neoplasia (HGPIN) has been identified as a
premalignant change in the prostate that indicates increased risk of the subsequent …

High-grade prostatic intraepithelial neoplasia (HGPIN) is believed to be a precursor for
prostatic adenocarcinoma. The prevalence of prostatic intraepithelial neoplasia (PIN) …

High‐grade prostatic intraepithelial neoplasia (HGPIN) appears to represent an ideal target
for chemoprevention of prostate cancer (PCa). HGPIN responds to androgen ablation and …

OBJECTIVES: The objective of this study was to evaluate efficacy, safety, and dose-
response profiles of four dosing schemes of flutamide over 24 weeks. METHODS: Patients …

Patients diagnosed as having benign prostatic hyperplasia (BPH) had determination of
prostate volume (PV), prostate‐specific antigen (PSA), and serum testosterone before …

Background: Some authors have recently reported that maximum androgen block (MAB), in
which the nonsteroidal anti–androgen, flutamide, is used together with conventional …

Backgroound The best treatment for patients with “hormone-refractory” metastatic prostate
cancer is unclear, particularly in patients for whom suramin and hydrocortisone have failed …

OBJECTIVE To investigate the efficacy of low‐dose flutamide (125 mg twice daily) in the
treatment of prostate‐specific antigen (PSA) recurrence after definitive treatment with radical …

PURPOSE To evaluate the effect of discontinuation of the antiandrogen, flutamide, in
patients with metastatic prostate cancer who are progressing on hormonal therapy …

Purpose We performed a randomized trial to compare the efficacy and toxicity of a new dose
of flutamide (500 mg QD) with the currently recommended dose (250 mg q8h) in the …