The highly disagreeable sensation of pain results from an extraordinarily complex and
interactive series of mechanisms integrated at all levels of the neuroaxis, from the periphery …

Pain is detected by two different types of peripheral nociceptor neurons, C-fiber nociceptors
with slowly conducting unmyelinated axons, and A-delta nociceptors with thinly myelinated …

Disease and injury frequently result in pain and hyperalgesia. These abnormal sensory
events arise in part from the action of inflammatory mediators on the peripheral terminals of …

Pain research has uncovered important neuronal mechanisms that underlie clinically
relevant pain states such as inflammatory and neuropathic pain. Importantly, both the …

This review summarizes recent findings on peripheral mechanisms underlying the
generation and inhibition of pain. The focus is on events occurring in peripheral injured …

Tissue injury is associated with sensitization of nociceptors and subsequent changes in the
excitability of central (spinal) neurons, termed central sensitization. Nociceptor sensitization …

Nociception provides a means of neural feedback that allows the central nervous system
(CNS) to detect and avoid noxious and potentially damaging stimuli in both active and …

This commentary on ideas about neural mechanisms underlying pain is aimed at providing
perspective for a reader who does not work in the field of mammalian somatic sensation. It is …

Chronic pain affects the lives of millions of people, and its treatment remains one of the most
challenging problems faced by clinicians who can offer their patients few if any effective …

Clinical pain is a serious public health issue. Treatment of pain-related suffering requires
knowledge of how pain signals are initially interpreted and subsequently transmitted and …