Abstract Evaluation of the cytotoxicity of novel octahydropyrazin [2, 1-a: 5, 4-a′]
diisoquinoline derivatives (1a–2c) employing a 3-(4, 5-dimethylthiazol-2-yl)-2, 5 …

In this study, we evaluated the cytotoxic activity and antiproliferative potency of novel
octahydropyrazin [2, 1-a: 5, 4-a′] diisoquinoline derivatives (1–7) in MCF-7 and MDA-MB …

A series of proline analogues of anthraquinone-2-carboxylic acid (1–3) were synthesized
and evaluated for cytotoxic activity in the cultured breast cancer MCF-7 cells. The …

Background: Pyrrolo [2, 3-d] pyrimidines have been recently reported to have anticancer
activities through inhibition of different targets such as, Epidermal Growth Factor Receptor …

Different quinazoline derivatives have showed wide spectrum of pharmacological activities.
Some 3-(arylideneamino)-phenylquinazoline-4 (3H)-ones have been reported to possess …

Pyrazoline is an important 5-membered nitrogen heterocycle that has been extensively
researched. Ten derivatives were synthesized and tested for antileukemic effects on 2 …

In a search for new compounds possessing antitumor activity, we examined the effects of a
group of oxygen containing heterocyclic derivatives on L1210 murine leukemia cell growth …

Objective The aim of the current study was to examine the anticancer activity and the
detailed mechanism of novel diisoquinoline derivatives in human gastric cancer cells (AGS) …

Abstract A series of 4-(4-substituted piperazin)-5, 6, 7-trialkoxy quinazoline was prepared by
conventional heating methods. Among these compounds, the crystal structure of compound …

The substituted chloroisoquinolinediones and pyrido [3, 4-b] phenazinediones were
synthesized, and the cytotoxic activity and topoisomerase II inhibitory activity of the prepared …