Postnatal developmental stages of lung parenchyma in rhesus monkeys is about one-third
that of humans. Alveoli in humans are reported to be formed up to 8 yr of age. We used …

Alveolarization in humans and nonhuman primates begins during prenatal development.
Advances in stereological counting techniques allow accurate assessment of alveolar …

Postnatal lung maturation generates a large number of small alveoli, with concomitant
thinning of alveolar septal walls, generating a large gas exchange surface area but …

BY DEVELOPMENTAL alveologenesis, we mean the formation of mature pulmonary gas-
exchange units (alveoli) that occurs during the overall maturation of the organism …

Previous studies of alveolarization have used rats or lambs; however, neither closely reflects
human alveolar development. We characterized alveolar development in rabbits (n= 3 …

We used three-dimensional reconstruction 1) to determine the effect of treating rats with
dexamethasone, from age 4 to 13 days, on alveolar volume (v) and number (Na) and 2) to …

Estimation of alveolar number in the lung has traditionally been done by assuming a
geometric shape and counting alveolar profiles in single, independent sections. In this study …

Nonpregnant female rats were kept in 13% O2 for greater than 3 wk before being bred,
throughout pregna ncy, and, with their pups, after birth; control rats were only in air. The …

Postnatal lung development is not well characterized in mice, especially the time point when
alveolarization is completed. Using the total length and the length density of the free septal …

Aging is associated with morphometric changes in the lung that lead to decreased lung
function. The nonhuman primate lung has been shown to have similar architectural …