Adenosine A2A receptor modulates neuroimmune function through Th17/retinoid-related orphan receptor gamma t (RORγt) signaling in a BTBR T+ Itpr3tf/J mouse …

MA Ansari, A Nadeem, SM Attia, SA Bakheet, M Raish… - Cellular …, 2017 - Elsevier
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder characterized
by abnormal social interactions, repetitive behaviors that impair social communication, and …

Activation of adenosine A2A receptor signaling regulates the expression of cytokines associated with immunologic dysfunction in BTBR T+ Itpr3tf/J mice

MA Ansari, SM Attia, A Nadeem, SA Bakheet… - Molecular and Cellular …, 2017 - Elsevier
Autism spectrum disorder (ASD) is neurodevelopmental disorders characterized by
stereotypical repetitive behavior, impaired social interaction, and deficits in communication …

Adenosine A2A receptor signaling affects IL-21/IL-22 cytokines and GATA3/T-bet transcription factor expression in CD4+ T cells from a BTBR T+ Itpr3tf/J mouse model …

SF Ahmad, MA Ansari, A Nadeem, SA Bakheet… - Journal of …, 2017 - Elsevier
Autism is a complex heterogeneous neurodevelopmental disorder; previous studies have
identified altered immune responses among individuals diagnosed with autism. An …

Toll-like receptors, NF-κB, and IL-27 mediate adenosine A2A receptor signaling in BTBR T+ Itpr3tf/J mice

SF Ahmad, MA Ansari, A Nadeem, SA Bakheet… - Progress in Neuro …, 2017 - Elsevier
Autism is a predominant neurodevelopmental disorder characterized by impaired
communication, social deficits, and repetitive behaviors. Recent research has proposed that …

Immune Alterations in CD8+ T Cells Are Associated with Neuronal CC and CXC Chemokine Receptor Regulation Through Adenosine A2A Receptor Signaling in a BTBR T+ …

SF Ahmad, MA Ansari, A Nadeem, SA Bakheet… - Molecular …, 2018 - Springer
Associative studies on a range of neurodevelopmental disorders have identified
relationships between behavioral deficits and immune system function. The BTBR T+ Itpr3 …

5-aminoisoquinolinone attenuates social behavior deficits and immune abnormalities in the BTBR T+ Itpr3tf/J mouse model for autism

SF Ahmad, MA Ansari, A Nadeem, SA Bakheet… - Pharmacology …, 2020 - Elsevier
Autism spectrum disorder (ASD) is diagnosed by core symptoms including impaired social
communication and the presence of repetitive and stereotypical behaviors. There is also …

5-Aminoisoquinolinone, a PARP-1 inhibitor, ameliorates immune abnormalities through upregulation of anti-inflammatory and downregulation of inflammatory …

K Alhosaini, MA Ansari, A Nadeem, SA Bakheet… - Brain Sciences, 2021 - mdpi.com
Autism spectrum disorder (ASD) covers a range of neurodevelopmental disorders involving
impairments in communication and repetitive and stereotyped patterns of behavior and …

Protection by tyrosine kinase inhibitor, tyrphostin AG126, through the suppression of IL-17A, RORγt, and T-bet signaling, in the BTBR mouse model of autism

SF Ahmad, MA Ansari, A Nadeem, SA Bakheet… - Brain Research …, 2018 - Elsevier
Autism spectrum disorder (ASD) is an extremely predominant neurodevelopmental disorder
expressed as impairment in reciprocal social interaction along with repetitive, restricted, and …

Resveratrol ameliorates dysregulation of Th1, Th2, Th17, and T regulatory cell-related transcription factor signaling in a BTBR T+ tf/J mouse model of autism

SA Bakheet, MZ Alzahrani, MA Ansari, A Nadeem… - Molecular …, 2017 - Springer
Autism spectrum disorder (ASD) is a neurodevelopmental disorder. It is characterized by
impaired social communication, abnormal social interactions, and repetitive behaviors …

Impact of suppressing retinoic acid-related orphan receptor gamma t (ROR)γt in ameliorating central nervous system autoimmunity

Y Yang, RC Winger, PW Lee… - Clinical & …, 2015 - academic.oup.com
Multiple sclerosis (MS) is an immune-mediated chronic central nervous system (CNS)
disease affecting more than 400 000 people in the United States. Myelin-reactive CD4 T …