Aliment Pharmacol Ther 2010; 32: 289–295 Summary Background Administration of 5‐
hydroxytryptamine (5HT) and selective 5HT receptor ligands modifies interdigestive motility …

Background: Little is known about the effect of 5‐hydroxytryptamine 1 (5‐HT1) receptor
agonism on the co‐ordinated motor activity of the gastric antrum, pylorus and duodenum …

Aims 5‐hydroxytryptamine3 receptor antagonists act antiemetically and slow colonic transit.
This study evaluated effects of the high‐affinity 5‐HT3 antagonist, cilansetron, on fasting …

Background It is unclear whether decreased serotonin transporter function contributes to
sensorimotor abnormalities in irritable bowel syndrome. Aim To study the influence of acute …

Summary Background: Although 5‐HT3 antagonists have been used to treat chemotherapy‐
induced emesis and diarrhoea‐predominant irritable bowel syndrome, the effects of 5‐HT3 …

Background—Pharmacological studies of the enteric nervous system have shown the
presence of several subtypes of 5-hydroxytryptamine (5HT) receptor, which might be …

Background: Prucalopride is a selective and specific 5‐hydroxytryptamine4 receptor agonist
that is known to increase stool frequency and to accelerate colonic transit. Aim: To …

BACKGROUND Serotonin 5-HT4 receptors are located on enteric cholinergic neurones and
may regulate peristalsis. 5-HT4 receptors on primary afferent neurones have been …

Aliment Pharmacol Ther 2011; 33: 395–402 Summary Background It is unclear whether
endogenous serotonin release is involved in the regulation of gastric motility and food …

Mosapride citrate (mosapride), a substituted benzamide, is a selective 5‐HT4 receptor
agonist, and is known to have prokinetic properties on the stomach. However, it is unclear …