Pharmacological response depends on multiple factors and one of them is sex–gender.
Data on the specific effects of sex–gender on pharmacokinetics, as well as the safety and …

The Food and Drug Administration (FDA) reviewed 300 new drug applications between
1995 and 2000. Of the 163 that included a sex analysis, 11 drugs showed a> 40% difference …

Abstract Professor Henry Higgins in My Fair Lady said,'Why can'ta woman be more like a
man?'Perhaps unintended, such narration extends to the reality of current drug …

Significant differences that exist between the sexes affect the prevalence, incidence and
severity of a broad range of diseases and conditions. Men and women also differ in their …

Gender-related differences in pharmacokinetics have frequently been considered as
potentially important determinants for the clinical effectiveness of drug therapy. The …

There are a number of examples of sex differences in drug pharmacokinetics and
pharmacodynamics. Recent advances in the characterisation of specific isozymes involved …

In humans, the combination of all sex-specific genetic, epigenetic, and hormonal influences
of biologic sex produces different in vivo environments for male and female cells. We dissect …

Several years ago regulatory authorities requested to include women in all phases of clinical
drug development in order to thoroughly investigate potential gender differences in the …

This review summarizes gender differences (GDs) in drug response. Although GDs have
been described both in pharmacodynamics and pharmacokinetics, their role in clinical …

Clinical data suggest that gender dimorphic profiles are emerging in terms of both drug
efficacy and adverse drug reactions (ADRs). With an increasing emphasis on individualised …