Suramin is a polyanionic compound currently used under evaluation for antineoplastic
activity. One of the main problems encountered during clinical trials was an adverse …

Suramin has shown promising antitumour activity against several tumour types, both in vitro
and in vivo, but the clinical utility of this compound is hampered by its unfavourable toxicity …

Conclusion and perspectives At present the primary mechanism (s) of suramin action is not
known. It is possible that several of the factors mentioned in this review are of importance for …

The antineoplastic activity of suramin is currently the subject of clinical trials. We therefore
used the semi‐automated fluoro‐metric microculture cytotoxicity assay (FMCA) to evaluate …

Suramin, a polysulfonated naphthylurea, is currently under investigation for treatment of
advanced malignancy and has been shown to exhibit antiproliferative effects on some cells …

Suramin is a polysulphonated naphthylurea currently investigated for the treatment of
advanced malignancy. In the present study, we have analysed the uptake and the …

Suramin is a polysulfonated compound currently under investigation for the treatment of
various types of cancer. Pharmacokinetic studies from clinical trials in humans have shown …

Twenty-five cell lines derived from nine different human cancers were tested for the cytotoxic
activity of suramin. Two different initial cellular concentrations were used: C1 (800–2000 …

Suramin is a polysulfonated naphthylurea currently investigated for the treatment of
advanced malignancy. We have previously reported that suramin was a potent inducer of …

Suramin is a polysulfonated compound originally developed nearly 75 years ago for use as
a trypanocidal agent. Recent studies indicate that suramin can also disrupt mammalian cell …