It is difficult to be the devil's advocate, the role of Caroline Papeix and Catherine Lubetzki,
since the evidence, admittedly circumstantial and inferential, suggests that a) vitamin D in …

Conclusion Although genetic and epidemiological data are interesting, available evidence
supporting vitamin D supplementation in MS is still lacking. We believe that vitamin D …

D3 serum levels above 100 nmol/l on average, a concentration that can be achieved by
taking 2000–4000 IU/day of vitamin D3. These doses are considered safe and potentially …

Clinical and pathological studies would suggest that multiple sclerosis is a heterogeneous
disease with individual patients varying dramatically in the extent of inflammatory change …

You recently published a letter by Dr. Fragoso and colleagues [1] that provided a short
description of 21 patients with relapsing remitting multiple sclerosis (MS) who were treated …

Low serum levels of 25-hydroxyvitamin D [25 (OH) D] and low sunlight exposure are known
risk factors for the development of multiple sclerosis. Add-on vitamin D supplementation …

An increase in the number of multiple sclerosis (MS) cases is seen with increasing distance
from the equator. This has directed attention toward vitamin D, which is synthesized in our …

IN MS? Vitamin D is a vitamin that acts like a hormone in the human body. We get vitamin D
from sunlight, food, or dietary supplements. The study by Stein et al. 1 examines the …

In the present issue's 'Controversies in Multiple Sclerosis', the authors argue the merits of
vitamin D's role in multiple sclerosis (MS). Manousaki and Richards (the 'Yes' camp), on one …

We thank Shukla et al. for their critical appraisal of our work. Regarding the first comment:
we agree, as already mentioned in the manuscript, that our exploratory study has its …