[HTML][HTML] A genome-wide association study of anorexia nervosa suggests a risk locus implicated in dysregulated leptin signaling

D Li, X Chang, JJ Connolly, L Tian, Y Liu, EJ Bhoj… - Scientific reports, 2017 - nature.com
We conducted a genome-wide association study (GWAS) of anorexia nervosa (AN) using a
stringently defined phenotype. Analysis of phenotypic variability led to the identification of a …

[HTML][HTML] Suggestive evidence for causal effect of leptin levels on risk for anorexia nervosa: Results of a mendelian randomization study

T Peters, J Antel, R Naaresh, BH Laabs… - Frontiers in …, 2021 - frontiersin.org
Genetic correlations suggest a coexisting genetic predisposition to both low leptin levels and
risk for anorexia nervosa (AN). To investigate the causality and direction of these …

Genetics of anorexia nervosa: An overview of genome-wide association studies and emerging biological links

C de Jorge Martínez, G Rukh, MJ Williams… - Journal of Genetics and …, 2022 - Elsevier
Anorexia nervosa (AN) is a complex disorder with a strong genetic component.
Comorbidities are frequent and there is substantial overlap with other disorders. The lack of …

Genetic contributions to the etiology of anorexia nervosa: New perspectives in molecular diagnosis and treatment

S Paolacci, AK Kiani, E Manara… - Molecular genetics & …, 2020 - Wiley Online Library
Background Anorexia nervosa is a multifactorial eating disorder that manifests with self‐
starvation, extreme anxiety, hyperactivity, and amenorrhea. Long‐term effects include organ …

[HTML][HTML] Investigation of common, low-frequency and rare genome-wide variation in anorexia nervosa

LM Huckins, K Hatzikotoulas, L Southam… - Molecular …, 2018 - nature.com
Anorexia nervosa (AN) is a complex neuropsychiatric disorder presenting with dangerously
low body weight, and a deep and persistent fear of gaining weight. To date, only one …

A genome-wide association study of anorexia nervosa

V Boraska, CS Franklin, JAB Floyd, LM Thornton… - Molecular …, 2014 - nature.com
Anorexia nervosa (AN) is a complex and heritable eating disorder characterized by
dangerously low body weight. Neither candidate gene studies nor an initial genome-wide …

The role of leptin, melanocortin, and neurotrophin system genes on body weight in anorexia nervosa and bulimia nervosa

Z Yilmaz, AS Kaplan, AK Tiwari, RD Levitan… - Journal of psychiatric …, 2014 - Elsevier
Objective Although low weight is a key factor contributing to the high mortality in anorexia
nervosa (AN), it is unclear how AN patients sustain low weight compared with bulimia …

[HTML][HTML] Genetic and epigenetic findings in anorexia nervosa

R Hirtz, A Hinney - Medizinische Genetik, 2020 - degruyter.com
Polygenic factors are relevant for the genetic predispositions to the eating disorder anorexia
nervosa (AN). The most recent genome-wide association study (GWAS) for AN comprised …

Brain-based gene expression of putative risk genes for anorexia nervosa

SB Murray, J Rokicki, AM Sartorius, A Winterton… - Molecular …, 2023 - nature.com
The etiology of anorexia nervosa (AN) remains elusive. Recent genome-wide association
studies identified the first genes liked to AN which reached genome-wide significance …

De novo deleterious variants that may alter the dopaminergic reward pathway are associated with anorexia nervosa

T Bienvenu, N Lebrun, J Clarke, P Duriez… - Eating and Weight …, 2020 - Springer
Purpose Anorexia nervosa (AN) is a complex neuropsychiatric disorder presenting with
dangerously low body weight, and a deep and persistent fear of gaining weight. Up to now …