[HTML][HTML] A genome-wide association study of anorexia nervosa suggests a risk locus implicated in dysregulated leptin signaling
We conducted a genome-wide association study (GWAS) of anorexia nervosa (AN) using a
stringently defined phenotype. Analysis of phenotypic variability led to the identification of a …
stringently defined phenotype. Analysis of phenotypic variability led to the identification of a …
[HTML][HTML] Suggestive evidence for causal effect of leptin levels on risk for anorexia nervosa: Results of a mendelian randomization study
Genetic correlations suggest a coexisting genetic predisposition to both low leptin levels and
risk for anorexia nervosa (AN). To investigate the causality and direction of these …
risk for anorexia nervosa (AN). To investigate the causality and direction of these …
Genetics of anorexia nervosa: An overview of genome-wide association studies and emerging biological links
C de Jorge Martínez, G Rukh, MJ Williams… - Journal of Genetics and …, 2022 - Elsevier
Anorexia nervosa (AN) is a complex disorder with a strong genetic component.
Comorbidities are frequent and there is substantial overlap with other disorders. The lack of …
Comorbidities are frequent and there is substantial overlap with other disorders. The lack of …
Genetic contributions to the etiology of anorexia nervosa: New perspectives in molecular diagnosis and treatment
Background Anorexia nervosa is a multifactorial eating disorder that manifests with self‐
starvation, extreme anxiety, hyperactivity, and amenorrhea. Long‐term effects include organ …
starvation, extreme anxiety, hyperactivity, and amenorrhea. Long‐term effects include organ …
[HTML][HTML] Investigation of common, low-frequency and rare genome-wide variation in anorexia nervosa
LM Huckins, K Hatzikotoulas, L Southam… - Molecular …, 2018 - nature.com
Anorexia nervosa (AN) is a complex neuropsychiatric disorder presenting with dangerously
low body weight, and a deep and persistent fear of gaining weight. To date, only one …
low body weight, and a deep and persistent fear of gaining weight. To date, only one …
A genome-wide association study of anorexia nervosa
V Boraska, CS Franklin, JAB Floyd, LM Thornton… - Molecular …, 2014 - nature.com
Anorexia nervosa (AN) is a complex and heritable eating disorder characterized by
dangerously low body weight. Neither candidate gene studies nor an initial genome-wide …
dangerously low body weight. Neither candidate gene studies nor an initial genome-wide …
The role of leptin, melanocortin, and neurotrophin system genes on body weight in anorexia nervosa and bulimia nervosa
Z Yilmaz, AS Kaplan, AK Tiwari, RD Levitan… - Journal of psychiatric …, 2014 - Elsevier
Objective Although low weight is a key factor contributing to the high mortality in anorexia
nervosa (AN), it is unclear how AN patients sustain low weight compared with bulimia …
nervosa (AN), it is unclear how AN patients sustain low weight compared with bulimia …
[HTML][HTML] Genetic and epigenetic findings in anorexia nervosa
R Hirtz, A Hinney - Medizinische Genetik, 2020 - degruyter.com
Polygenic factors are relevant for the genetic predispositions to the eating disorder anorexia
nervosa (AN). The most recent genome-wide association study (GWAS) for AN comprised …
nervosa (AN). The most recent genome-wide association study (GWAS) for AN comprised …
Brain-based gene expression of putative risk genes for anorexia nervosa
The etiology of anorexia nervosa (AN) remains elusive. Recent genome-wide association
studies identified the first genes liked to AN which reached genome-wide significance …
studies identified the first genes liked to AN which reached genome-wide significance …
De novo deleterious variants that may alter the dopaminergic reward pathway are associated with anorexia nervosa
T Bienvenu, N Lebrun, J Clarke, P Duriez… - Eating and Weight …, 2020 - Springer
Purpose Anorexia nervosa (AN) is a complex neuropsychiatric disorder presenting with
dangerously low body weight, and a deep and persistent fear of gaining weight. Up to now …
dangerously low body weight, and a deep and persistent fear of gaining weight. Up to now …