Pancreatic islets are highly vascularized mini-organs, and vascular endothelial growth factor
(VEGF)-A is a critical factor in the development of islet vascularization. To investigate the …

To investigate molecular mechanisms controlling islet vascularization and revascularization
after transplantation, we examined pancreatic expression of three families of angiogenic …

There is a reciprocal interaction between pancreatic islet cells and vascular endothelial cells
(EC) in which EC-derived signals promote islet cell differentiation and islet development …

VEGF-A expression in beta cells is critical for pancreatic development, formation of islet-
specific vasculature, and Insulin secretion. However, two key questions remain. First, is …

Blood vessel endothelium has been recently shown to induce endocrine pancreatic
development [1]. Because pancreatic endocrine cells or islets express high levels of …

the islet contains a dense vascular structure of several features. the expression of vascular
endothelial growth factor (VEGF)-A in beta cells is indispensable for the formation of this …

Pancreatic islet endocrine cell and endothelial cell (EC) interactions mediated by vascular
endothelial growth factor-A (VEGF-A) signaling are important for islet differentiation and the …

Reciprocal signalling between the endothelium and the pancreatic epithelium is crucial for
coordinated differentiation of the embryonic endocrine and exocrine pancreas. In the adult …

Background. Blood flow is impaired in islet transplants, but there is conflicting evidence on
improving the outcome by promoting vascularization. We previously reported that islet …

Type 2 diabetes (T2D) results from insulin resistance and inadequate insulin secretion.
Insulin resistance initially causes compensatory islet hyperplasia that progresses to islet …