The histamine H3 receptor mediates inhibitory responses in the nervous system. Here, we
demonstrate the coupling of the human histamine H3 receptor to G protein-coupled inward …

The recently cloned histamine H4 receptor is expressed predominantly in haematopoietic
cells and has been found to modulate the function of mast cells, eosinophils, dendritic cells …

Agonist potency at some neurotransmitter receptors has been shown to be regulated by
voltage, a mechanism which has been suggested to play a crucial role in the regulation of …

Abstract Histamine H 3 receptors (H 3 Rs) modulate the function of the nervous system at the
pre-and post-synaptic levels. In this work we aimed to determine whether, as other G protein …

Histamine receptors (HRs) are G-protein-coupled receptors involved in diverse responses
triggered by histamine release during inflammation or by encounters with venomous …

The distribution of histaminergic fibers in the zebrafish brain was recently shown to resemble
that in mammals. Expression of l‐histidine decarboxylase (HDC) mRNA was shown only in …

Background and purpose: The histamine H4 receptor is the most recently identified of the G
protein‐coupled histamine receptor family and binds several neuroactive drugs, including …

Histamine is involved in many physiological functions in the periphery and is an important
neurotransmitter in the brain. It acts on metabotropic H1–H4 receptors mediating …

Ligand pharmacology of histamine H3-receptors is species-dependent. In previous studies,
two amino acids in transmembrane domain 3 (TM III) were shown to play a significant role. In …

The predominant histamine receptor subtype in the supraventricular and ventricular tissue of
various mammalian species is the H2 receptor (H2-R) subtype, which is known to couple to …