Objective Hyperactivation of innate immunity by Toll‐like receptors (TLRs) can contribute to
the development of autoinflammatory or autoimmune diseases. This study evaluated the …

Rheumatoid Arthritis (RA) is the most common chronic inflammatory autoimmune disease
involving joints. Among several pathogenic mechanisms, the impairment of homeostatic …

Osteoarthritis (OA) is the most prevalent joint disease, and it is characterized by cartilage
degeneration, synovitis, and bone sclerosis, resulting in swelling, stiffness, and joint pain …

Abstract Tyro3, Axl, and Mertk (abbreviated TAMs) comprise a family of homologous type 1
receptor tyrosine kinases (RTKs) that have been implicated as inhibitory receptors that …

Introduction The TAM (tyro 3, axl, mer) kinases are key regulators of innate immunity and are
important in the phagocytosis of apoptotic cells. Gas6 and protein S are ligands for these …

The TAM tyrosine kinases, Axl and MerTK, play an important role in rheumatoid arthritis
(RA). Here, using a unique synovial tissue bioresource of patients with RA matched for …

Rheumatoid arthritis is an auto-immune disease of the synovial joints, hallmarked by chronic
inflammation and subsequent progressive tissue destruction. TYRO3, AXL and MER (gene …

Objective To test whether the tyrosine kinase Tyro3 affects arthritis. Tyro3, the ligand of
growth arrest–specific protein 6 (GAS6) is a receptor tyrosine kinase involved in cell survival …

Abstract Introduction Toll-like receptors (TLRs) are likely to play crucial roles in the
pathogenesis of rheumatoid arthritis (RA). The aim of this study was to determine the key …

Objective To investigate the role of AXL, a member of the anti-inflammatory TYRO3, AXL
MER (TAM) receptor family, in arthritis. Methods KRN serum transfer arthritis was induced in …