Inflammatory bowel disease: progress and current concepts of etiopathogenesis

F Scaldaferri, C Fiocchi - Journal of digestive diseases, 2007 - Wiley Online Library
Over the past few years, none of the numerous conditions that are grouped under the broad
designation of 'chronic inflammatory or autoimmune disorders' has undergone as much …

Inflammatory bowel disease: Established and evolving considerations on its etiopathogenesis and therapy

A Schirbel, C Fiocchi - Journal of digestive diseases, 2010 - Wiley Online Library
Modern studies of inflammatory bowel disease (IBD) pathogenesis have been pursued for
about four decades, a period of time where the pace of progress has been steadily …

Inflammatory bowel disease: past, present, and future

BE Sands - Journal of gastroenterology, 2007 - Springer
Crohn's disease and ulcerative colitis, collectively known as the inflammatory bowel
diseases (IBD), are largely diseases of the twentieth century, and are associated with the …

Recent understanding of IBD pathogenesis: implications for future therapies

T Kucharzik, C Maaser, A Lügering… - Inflammatory bowel …, 2006 - academic.oup.com
The inflammatory bowel diseases (IBD) are comprised of two major phenotypes, Crohn's
disease (CD) and ulcerative colitis (UC). Research over the last couple of years has led to …

Immunopathogenesis of IBD: current state of the art

HSP De Souza, C Fiocchi - Nature reviews Gastroenterology & …, 2016 - nature.com
IBD is a chronic inflammatory condition of the gastrointestinal tract encompassing two main
clinical entities: Crohn's disease and ulcerative colitis. Although Crohn's disease and …

Evolving paradigms in the pathogenesis of IBD

L Mayer - Journal of gastroenterology, 2010 - Springer
The pathogenesis of all immune-mediated inflammatory diseases has been carefully studied
over the past several decades, but it is only recently that we have come to appreciate …

Inflammatory bowel disease: epidemiology, pathogenesis, and therapeutic opportunities

SB Hanauer - Inflammatory bowel diseases, 2006 - academic.oup.com
Ulcerative colitis (UC) and Crohn's disease (CD), the primary constituents of inflammatory
bowel disease (IBD), are precipitated by a complex interaction of environmental, genetic …

New insights into inflammatory bowel disease pathophysiology: paving the way for novel therapeutic targets

T Stefanelli, A Malesci, A Repici, S Vetrano… - Current Drug …, 2008 - ingentaconnect.com
The etiopathogenesis of Crohn's disease (CD) and ulcerative Colitis (UC), the two major
forms of inflammatory bowel disease (IBD), is still unknown. Although the exact cause and …

A tale of two diseases: the history of inflammatory bowel disease

DJ Mulder, AJ Noble, CJ Justinich… - Journal of Crohn's and …, 2014 - academic.oup.com
Abstract 'Inflammatory bowel disease'(IBD) sounds like a straightforward term—a disease of
inflammation in the bowel. However, the history of IBD reveals a story of a nefariously …

Current theories on the causes of inflammatory bowel disease

KA Papadakis, SR Targan - Gastroenterology Clinics of North America, 1999 - Elsevier
Chronic relapsing and remitting inflammation of the intestinal tract is the hallmark trait of
ulcerative colitis (UC) and Crohn's disease (CD), collectively termed inflammatory bowel …