Background: Peripheral opioid receptor targeting has been well established as a novel
target in clinical pain management for acute and chronic peripheral inflammatory pain. The …

Peripheral nerve damage can result in neuronal hyperexcitability, resulting in neuropathic
pain. Localized neuropathic pain is confined to a specific area not larger than a letter-size …

This study evaluates the prophylactic effect of the peripherally-selective mu-opioid receptor
agonist, loperamide, administered topically in a liposomal gel formulation on pain …

This study aimed to develop a suitable topical delivery system containing diethylene glycol
monoethyl ether (DGME) for Loperamide hydrochloride (Lop). Two factors, three levels …

The antihyperalgesic properties of the opiate antidiarrheal agent loperamide (ADL 2-1294)
were investigated in a variety of inflammatory pain models in rodents. Loperamide exhibited …

Background The analgesic properties and mechanisms of loperamide hydrochloride, a
peripherally acting opioid receptor agonist, in neuropathic pain warrant further investigation …

We evaluated the anti-edema/antinociceptive effects of subcutaneous free and liposomal
morphine in rats with carrageenan-induced inflammation of the paw. We assessed …

Chronic pain affects over 1.5 billion people worldwide and decreases activity to diminish
people's quality‐of‐life. Traditional opioids (eg, morphine) are the gold standards for treating …

Trigeminal neuralgia is a chronic pain syndrome in which patients experience intense
paroxysms of lancinating pain in the face along the distribution of one or more branches of …