Introduction Type 1 collagen forms> 90% of the organic matrix of bone. Bone is continually
being remodelled, where type 1 collagen is broken down and renewed. During this …

Measuring bone turnover markers could detect early stages of osteoporosis and early
responses to anti-osteoporotic treatments. Currently, commonly used bone turnover …

Bone is a dynamic tissue that undergoes constant remodeling, serving crucial roles in
mechanical support, organ protection, locomotion, blood cell production, and mineral …

In the last few years, research on the use of biochemical markers of bone turnover has
greatly improved. Among the several available bone turnover markers, monitoring serum C …

Serum CTX assays measure a fragment of the C-terminal telopeptide of type 1 collagen
released during resorption of mature bone. Assay reagents are available in manual and …

Roche Diagnostics recently automated (1)(on the Elecsys® analyzer) the-CrossLapsTM
assay (2) for measurement of bone-derived degradation products of type I collagen carboxy …

• C-terminal cross-linked telopeptide (CTX) are part of bone turnover biomarkers.• Analytical
performances of a new CTX automated were evaluated.• Our results showed a good …

Osteoporosis is a disease where increased bone weakness increases the risk of a broken
bone. Until a broken bone occurs, there are typically no symptoms. Osteoporosis affects …

[CTX] and N-telopeptides to helix [NTX]). 14, 18 The compounds acting as crosslinks are
formed during bone maturation. The 2 best-characterized collagen crosslinks are …

1 Laboratory of Clinical Chemistry, CIRM, University of Liège, Belgium 2 Department of
Clinical Chemistry, CHU of Liège, Belgium Type I collagen crosslinked telopeptide (β-CTX) …