A case of ganciclovir-resistant cytomegalovirus (CMV) retinitis in a patient with AIDS: longitudinal molecular analysis of the CMV viral load and viral mutations in blood …

G Boivin, C Gilbert, M Morissette, J Handfield… - Aids, 1997 - journals.lww.com
Objectives: To study the temporal relationships between cytomegalovirus (CMV) viral load
and specific UL97 mutations in polymorphonuclear leukocytes (PMNL) and plasma samples …

Emergence and prevalence of cytomegalovirus UL97 mutations associated with ganciclovir resistance in AIDS patients

C Gilbert, J Handfield, E Toma, R Lalonde… - Aids, 1998 - journals.lww.com
Objectives: To evaluate the prevalence of the most common cytomegalovirus (CMV) UL97
mutations associated with ganciclovir resistance directly in polymorphonuclear leukocytes …

Discordant phenotypes and genotypes of cytomegalovirus (CMV) in patients with AIDS and relapsing CMV retinitis

C Gilbert, G Boivin - Aids, 2003 - journals.lww.com
Objective: To investigate the correlation between genotypic studies performed on blood
leukocytes and phenotypic results obtained from the corresponding blood viral isolates in …

Cytomegalovirus polymerase chain reaction viraemia in patients receiving ganciclovir maintenance therapy for retinitis

FE Bowen, VC Emery, P Wilson, MA Johnson… - Aids, 1998 - journals.lww.com
Objectives: To determine whether recurrence of polymerase chain reaction (PCR) viraemia
during maintenance ganciclovir for cytomegalovirus (CMV) retinitis correlates with (i) CMV …

Detection of ganciclovir resistance in patients with AIDS and cytomegalovirus retinitis: correlation of genotypic methods with viral phenotype and clinical outcome

DA Jabs, BK Martin, MO Ricks… - Journal of Infectious …, 2006 - academic.oup.com
Abstract Background The cytomegalovirus (CMV) UL97 gene can be sequenced either from
blood specimens directly amplified by polymerase chain reaction (PCR) or from culture …

Polyradiculopathy associated with ganciclovir-resistant cytomegalovirus in an AIDS patient: phenotypic and genotypic characterization of sequential virus isolates

IL Smith, M Shinkai, WR Freeman… - Journal of Infectious …, 1996 - academic.oup.com
To investigate the role of antiviral drug resistance in cytomegalovirus (CMV) disease
progression, CMV cultured from an AIDS patient who developed progressive CMV disease …

Rate of emergence of cytomegalovirus (CMV) mutations in leukocytes of patients with acquired immunodeficiency syndrome who are receiving valganciclovir as …

G Boivin, C Gilbert, A Gaudreau… - The Journal of …, 2001 - academic.oup.com
The emergence of mutations conferring ganciclovir resistance was evaluated in an open-
label randomized clinical trial that compared oral valganciclovir with intravenous ganciclovir …

Ganciclovir resistance and UL97 gene mutations in cytomegalovirus blood isolates from patients with AIDS treated with ganciclovir

B Abraham, S Lastere, J Reynes… - Journal of clinical …, 1999 - Elsevier
Background: Treatment of cytomegalovirus (CMV) diseases with protracted administration of
ganciclovir can promote the development of resistant CMV that is associated with a poor …

Mutations conferring ganciclovir resistance in a cohort of patients with acquired immunodeficiency syndrome and cytomegalovirus retinitis

DA Jabs, BK Martin, MS Forman… - The Journal of …, 2001 - academic.oup.com
Cytomegalovirus (CMV) retinitis is among the most common opportunistic infections in
patients with acquired immunodeficiency syndrome. In a prospective study of 210 patients …

Cytomegalovirus (CMV) resistance in patients with CMV retinitis and AIDS treated with oral or intravenous ganciclovir

WL Drew, MJ Stempien, J Andrews… - The Journal of …, 1999 - academic.oup.com
Abstract Treatment of cytomegalovirus (CMV) retinitis with oral ganciclovir results in
relatively low plasma concentrations of drug, which theoretically could cause more frequent …