Positive-and negative-control pathways by blood components for intermedilysin production in Streptococcus intermedius

T Tomoyasu, T Yamasaki, S Chiba, S Kusaka… - Infection and …, 2017 - Am Soc Microbiol
Streptococcus intermedius is an opportunistic bacterial pathogen secreting a human-specific
cytolysin called intermedilysin (ILY) as a major pathogenic factor. This bacterium can …

Role of Catabolite Control Protein A in the Regulation of Intermedilysin Production by Streptococcus intermedius

T Tomoyasu, A Tabata, R Hiroshima, H Imaki… - Infection and …, 2010 - Am Soc Microbiol
Streptococcus intermedius is an opportunistic pathogen of humans that causes purulent
infections, including brain and liver abscesses. This pathogen secretes a human-specific …

Distribution of the intermedilysin gene among the anginosus group streptococci and correlation between intermedilysin production and deep-seated infection with …

H Nagamune, RA Whiley, T Goto, Y Inai… - Journal of clinical …, 2000 - Am Soc Microbiol
The distribution of intermedilysin, a human-specific cytolysin, among the anginosus group
streptococci and the correlation of toxin production and infection by Streptococcus …

LacR mutations are frequently observed in Streptococcus intermedius and are responsible for increased intermedilysin production and virulence

T Tomoyasu, H Imaki, S Masuda, A Okamoto… - Infection and …, 2013 - Am Soc Microbiol
Streptococcus intermedius secretes a human-specific cytolysin, intermedilysin (ILY), which is
considered to be the major virulence factor of this pathogen. We screened for a repressor of …

Rapid screening method for detecting highly pathogenic Streptococcus intermedius strains carrying a mutation in the lacR gene

T Tomoyasu, M Matoba, A Takao… - FEMS microbiology …, 2018 - academic.oup.com
Streptococcus intermedius is a member of the normal human commensal flora and secretes
a human-specific cytolysin intermedilysin (ILY) as a major virulence factor. Expression of ily …

Intermedilysin plays a key role in the invasion of human cells by Streptococcus intermedius

H Nagamune, A Sukeno, RA Whiley, SI Jafar… - International Congress …, 2006 - Elsevier
Streptococcus intermedius, which causes endogenous infections leading to abscesses,
produces intermedilysin (ILY), a human-specific cytolysin. Because of the significant …

Intermedilysin Is Essential for the Invasion of Hepatoma HepG2 Cells by Streptococcus intermedius

A Sukeno, H Nagamune, RA Whiley… - Microbiology and …, 2005 - Wiley Online Library
Streptococcus intermedius causes endogenous infections leading to abscesses. This
species produces intermedilysin (ILY), a human‐specific cytolysin. Because of the significant …

Intermedilysin release by Streptococcus intermedius: effects of various antibacterial drugs at sub-MIC levels

MB Taylor, JHL Oh, KL Kang… - FEMS microbiology …, 2005 - academic.oup.com
Intermedilysin is a cytolytic toxin produced by Streptococcus intermedius, a pathogen of
humans. In vitro studies showed that exposure of S. intermedius to sub-minimum inhibitory …

Intermedilysin: A Cytolytic Toxin Specific for Human Cells of a Streptococcus intermedius Isolated from Human Liver Abscess

H Nagamune, C Ohnishi, A Katsuura, Y Taoka… - Streptococci and the …, 1997 - Springer
Streptococcus intermedius is one of the three distinct species classified into the
Streptococcus milleri-group (SMG, S. anginosus, S. constellatus and S. intermedius) which …

Effect on Polymorphonuclear Cell Function of a Human-Specific Cytotoxin, Intermedilysin, Expressed byStreptococcus intermedius

MG Macey, RA Whiley, L Miller… - Infection and …, 2001 - Am Soc Microbiol
Streptococcus intermedius is a member of the normal flora of the mouth but is also an
opportunistic pathogen associated with purulent infections at oral and nonoral sites …