Statins are increasingly being used for the treatment of a variety of conditions beyond their
original indication for cholesterol lowering. We previously reported that simvastatin …

Sprague–Dawley rats with unilateral lesion of the medial forebrain bundle by 6-
hydroxydopamine showed marked decrease in the expression of dopamine D1 and D2 …

Statins are increasingly being used for the treatment of a variety of conditions beyond their
original indication for cholesterol lowering. We previously reported that simvastatin affected …

Statins are widely being used for the treatment of a variety of conditions beyond their original
indication for lowering cholesterol. We have previously reported that simvastatin affected the …

High doses of simvastatin upregulate dopamine D1 and D2 receptor expression in the rat
prefrontal cortex: possible involvement of endothelial nitric oxide synthase - PMC Back to Top …

OBJECTIVE: The aim of this study is to investigate the antidepressant and anxiolytic effects
of simvastatin in rats. METHODS: Sixty-four male adult (8-9 weeks old) Sprague-Dawley rats …

Lipophilic statins which are blood brain barrier (BBB) permeable are speculated to affect the
cholesterol synthesis and neural functions in the central nervous system. However, whether …

On a global scale, there is an increasing tendency for a more aggressive treatment of
hypercholesterolemia. Minor effects of statins on brain cholesterol metabolism have been …

Atorvastatin is a statin largely used in the treatment of hypercholesterolemia and recently
revealed as a neuroprotective agent. The antidepressant-like effect of acute atorvastatin …

Statins are inhibitors of the enzyme 3-hydroxy-3-methylglutaryl coenzyme A reductase, the
rate-limiting step in cholesterol biosynthesis. Statins effectively prevent and reduce the risk …