Although the considerable progress against gastric cancer, it remains a complex lethal
disease defined by peculiar histological and molecular features. The purpose of the present …

Gastric carcinoma is one of the aggressive malignancies with poor prognosis. The
expression of pRb, Ki67, Her-2 in relation to tumor grade and stage in gastric carcinoma still …

Background The variability of prognosis within a pathological stage of gastric cancer (GC) at
presentation, underscores the need for specific biological markers to identify subgroups of …

We performed the immunohistochemical staining for six G1 check point cell cycle proteins to
study their expression patterns and roles in the gastric carcinogenesis. We studied 76 cases …

EZH2 is a core component of the polycomb repressive complex 2 (PRC2), which catalyzes
trimethylation of histone H3 lysine 27 (H3K27me3) and promotes carcinogenesis by …

Background: The tumor suppressor gene p53 is a nuclear protein which plays a key role in
tumor progression by regulating DNA repair, cell division and apoptosis. One major function …

AIM: To analyze the correlation between the protein expression of p16 and Rb genes in
gastric carcinoma (GC), to investigate the role of p16 gene in invasion and lymph node …

Background Cyclin E is a protein that plays a key role in the G1→ S transition of the normal
cell cycle. The product of retinoblastoma gene (pRb) is the master regulator of entry into the …

The adenoma‑carcinoma sequence, the sequential mutation and deletion of various genes
by which colorectal cancer progresses, is a well‑established and accepted concept of …

Objective: We aimed to investigate the biological significance of cell cycle regulators in
gastric carcinoma. Methods: Immunohistochemistry and TUNEL staining were performed on …