Although B lymphopoiesis is one of the best-defined paradigms in cell differentiation, our
knowledge of the regulatory mechanisms underlying its earliest processes, in which …

B-lymphocyte differentiation is one of the best understood developmental pathways in the
hematopoietic system. Our understanding of the developmental trajectories linking the …

The generation of B cells is the result of several cell lineage choices, cell commitment and
differentiation. These cellular transitions take place in a stepwise manner and are regulated …

The progression of hematopoietic stem cells (HSCs) to the B lymphocyte lineage requires
that uncommitted progenitors successfully negotiate the transition from multipotency to …

All mature blood cells derive from hematopoietic stem cells through gradual restriction of
their cell fate potential and acquisition of specialized functions. Lineage specification and …

Development of B-lymphoid cells is a highly ordered multi-step process that, in adult
mammals, starts in bone marrow in a pool of self-renewing multipotential hematopoietic …

Hematopoiesis is regulated by signals from the microenvironment, transcription factor
networks, and changes of the epigenetic landscape. Transcription factors interact with and …

The maturation of B‐lymphoid cells from hematopoietic stem cells in the bone marrow is a
complex process under control of interplay between extrinsic and intrinsic factors. In addition …

Powerful techniques—including gene targeting, genomic and proteomic analyses—are
allowing a more complete understanding of the transcription factors that drive B-cell …

B cell development is a multistep process that is tightly regulated at the transcriptional level.
In recent years, investigators have shed light on the transcription factor networks involved in …