Background Currently, there is clear evidence that apoptosis plays an important role in the
development and progression of tumors. One of the best characterized apoptosis triggering …

The CD95 pathway is a critical apoptotic pathway used by immune cells to avoid cancer
development. CD95 ligand (CD95L) is found in several forms, as a cell membrane …

CD95 (APO-1/Fas) is an important inducer of the extrinsic apoptosis signaling pathway and
therapy induced apoptosis of many tumor cells has been linked to the activity of CD95 …

Several malignant cell lines are resistant to CD95 (Apo1/Fas)-mediated apoptosis, even
when the CD95 receptor is highly expressed. Sensitivity to CD95-induced apoptosis can be …

Background Impaired regulation of apoptosis is known to be associated with the
development of various cancers. Fas receptor (APO‐1/CD95) binding to its ligand, Fas …

BACKGROUND Carcinomas of the skin are by far the most common human malignancies.
Continuous exposure to ultraviolet (UV) light facilitates the development of precancerous …

Abstract Fas/CD95/Apo1 is a transmembrane receptor known to trigger apoptotic cell death
in several cell types. In the present study, we showed that ionizing radiation (IR) and NO …

Abstract CD95 (APO-1/Fas) is a cell surface receptor that, when oligomerized by natural
ligand, CD95L, or antibody, confers an apoptotic signal to apoptosis-sensitive cells …

Abstract Background Fas (Apo-1/CD95) and its specific ligand (FasL) are key elements in
apoptosis. They have been studied in different malignancies but there are few published …

When cervical carcinoma cells were monitored for apoptotic signals, HPV18+ lines were
found to be highly sensitive to agonistic CD95 antibodies or recombinant CD95 ligands after …