Differentiation-inducing factor 1 activates cofilin through pyridoxal phosphatase and AMP-activated protein kinase, resulting in mitochondrial fission
T Inoue, K Miura, R Han, F Seto-Tetsuo… - Journal of …, 2023 - Elsevier
Abstract Differentiation-inducing factor 1 (DIF-1) is a morphogen produced by Dictyostelium
discoideum that inhibits the proliferation and migration of both D. discoideum and most …
discoideum that inhibits the proliferation and migration of both D. discoideum and most …
Cofilin1-dependent actin dynamics control DRP1-mediated mitochondrial fission
K Rehklau, L Hoffmann, CB Gurniak, M Ott… - Cell death & …, 2017 - nature.com
Mitochondria form highly dynamic networks in which organelles constantly fuse and divide.
The relevance of mitochondrial dynamics is evident from its implication in various human …
The relevance of mitochondrial dynamics is evident from its implication in various human …
Mitochondria Are the Target Organelle of Differentiation-Inducing Factor-3, an Anti-Tumor Agent Isolated from Dictyostelium Discoideum
Y Kubohara, H Kikuchi, Y Matsuo, Y Oshima… - PLoS …, 2013 - journals.plos.org
Differentiation-inducing factor-3 (DIF-3), found in the cellular slime mold Dictyostelium
discoideum, and its derivatives such as butoxy-DIF-3 (Bu-DIF-3) are potent anti-tumor …
discoideum, and its derivatives such as butoxy-DIF-3 (Bu-DIF-3) are potent anti-tumor …
[HTML][HTML] Differentiation inducing factor 3 mediates its anti-leukemic effect through ROS-dependent DRP1-mediated mitochondrial fission and induction of caspase …
A Dubois, C Ginet, N Furstoss, A Belaid… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Differentiation-inducing factor (DIF) defines a group of chlorinated hexaphenones that
orchestrate stalk-cell differentiation in the slime mold Dictyostelium discoideum (DD). DIF-1 …
orchestrate stalk-cell differentiation in the slime mold Dictyostelium discoideum (DD). DIF-1 …
Mitochondrial fission and mitophagy depend on cofilin-mediated actin depolymerization activity at the mitochondrial fission site
Mitochondria fission and mitophagy are fundamentally crucial to cellular physiology and
play important roles in cancer progression. Developing a comprehensive understanding of …
play important roles in cancer progression. Developing a comprehensive understanding of …
[HTML][HTML] Mitochondrial translocation and interaction of cofilin and Drp1 are required for erucin-induced mitochondrial fission and apoptosis
G Li, J Zhou, A Budhraja, X Hu, Y Chen, Q Cheng… - Oncotarget, 2015 - ncbi.nlm.nih.gov
Cofilin is a member of the actin-depolymerizing factor (ADF) family protein, which plays an
essential role in regulation of the mitochondrial apoptosis. It remains unclear how cofilin …
essential role in regulation of the mitochondrial apoptosis. It remains unclear how cofilin …
Evidence that differentiation-inducing factor-1 controls chemotaxis and cell differentiation, at least in part, via mitochondria in D. discoideum
Y Kubohara, H Kikuchi, VH Nguyen… - Biology …, 2017 - journals.biologists.com
ABSTRACT Differentiation-inducing factor-1 [1-(3, 5-dichloro-2, 6-dihydroxy-4-
methoxyphenyl) hexan-1-one (DIF-1)] is an important regulator of cell differentiation and …
methoxyphenyl) hexan-1-one (DIF-1)] is an important regulator of cell differentiation and …
Dictyostelium Differentiation-Inducing Factor 1 Promotes Glucose Uptake via Direct Inhibition of Mitochondrial Malate Dehydrogenase in Mouse 3T3-L1 Cells
Y Kubohara, Y Fukunaga, A Shigenaga… - International Journal of …, 2024 - mdpi.com
Differentiation-inducing factor 1 (DIF-1), found in Dictyostelium discoideum, has
antiproliferative and glucose-uptake-promoting activities in mammalian cells. DIF-1 is a …
antiproliferative and glucose-uptake-promoting activities in mammalian cells. DIF-1 is a …
Interaction of mitochondrial fission factor with dynamin related protein 1 governs physiological mitochondrial function in vivo
Mitochondria form a dynamic network governed by a balance between opposing fission and
fusion processes. Because excessive mitochondrial fission correlates with numerous …
fusion processes. Because excessive mitochondrial fission correlates with numerous …
Properties of a non-bioactive fluorescent derivative of differentiation-inducing factor-3, an anti-tumor agent found in Dictyostelium discoideum
Y Kubohara, H Kikuchi, Y Matsuo, Y Oshima… - Biology …, 2014 - journals.biologists.com
ABSTRACT Differentiation-inducing factor-3 (DIF-3), found in the cellular slime mold
Dictyostelium discoideum, and its derivatives, such as butoxy-DIF-3 (Bu-DIF-3), are potent …
Dictyostelium discoideum, and its derivatives, such as butoxy-DIF-3 (Bu-DIF-3), are potent …