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OBJECTIVE: The 5-alpha-reductase type 2 (5A2) enzyme catalyses the irreversible
conversion of testosterone to dihydrotestosterone, the most active androgen in the prostate …

Inhibitors of 5α-reductase (SRD5A) that lower intraprostatic levels of dihydrotestosterone
(DHT) reduce the overall incidence of prostate cancer (PCa), but there is significant variation …

Prostate cancer is a significant cause of death in Western countries and is under the strong
influence of androgens. The steroid 5α-reductase 2 catalyzes the metabolism of testosterone …

Purpose: Common treatments for benign prostatic hyperplasia include 5α-reductase
inhibitors and α-adrenergic receptor antagonists. However, these treatments can only …

BACKGROUND Emerging evidence indicates that testosterone (T), and not
dihydrotestosterone (DHT), is the most relevant androgen that promotes carcinogenesis in …

It has been suggested that the activity of the steroid 5α-reductase type II enzyme (encoded
by the SRD5A2 gene) may be associated with prostate cancer risk and that population …

Abstract 5α-Reductase type 2, the predominant prostatic isozyme of this protein, converts
testosterone to dihydrotestosterone. It has been hypothesized that individuals with greater …

INTRODUCTION AND OBJECTIVES: Steroid 5-alpha reductase (SRD5A2) is a critical
enzyme for prostatic development and growth. We have found that epigenetic modifications …

BACKGROUND Increasing studies investigating the association between steroid 5‐alpha
reductase type II gene polymorphism at codon 89 (SRD5A2 V89L) and susceptibility to …