Induced pluripotent stem cell (iPSCs) and their application in immunotherapy

Z Jiang, Y Han, X Cao - Cellular & molecular immunology, 2014 - nature.com
The ever-improving technology to generate induced pluripotent stem cells (iPSCs) has
increased their potential use as novel candidates for disease modeling, drug screening …

[HTML][HTML] Recent technological updates and clinical applications of induced pluripotent stem cells

S Diecke, SM Jung, J Lee, JH Ju - The Korean journal of internal …, 2014 - ncbi.nlm.nih.gov
Induced pluripotent stem cells (iPSCs) were first described in 2006 and have since emerged
as a promising cell source for clinical applications. The rapid progression in iPSC …

Roadblocks in the Path of iPSC to the Clinic

E Garreta, S Sanchez, J Lajara, N Montserrat… - Current transplantation …, 2018 - Springer
Abstract Purpose of Review The goal of this paper is to highlight the major challenges in the
translation of human pluripotent stem cells into a clinical setting. Recent Findings Innate …

Strategies to generate induced pluripotent stem cells

M Hayes, N Zavazava - … Stem Cell Immunobiology: Methods and Protocols, 2013 - Springer
The isolation of embryonic stem cells (ESCs) has furthered our understanding of normal
embryonic development and fueled the progression of stem cell derived therapies. However …

Autologous induced pluripotent stem cell–based cell therapies: Promise, progress, and challenges

M Madrid, C Sumen, S Aivio, N Saklayen - Current protocols, 2021 - Wiley Online Library
The promise of human induced pluripotent stem cells (iPSCs) lies in their ability to serve as
a starting material for autologous, or patient‐specific, stem cell–based therapies. Since the …

[HTML][HTML] Methods of induced pluripotent stem cells for clinical application

T Seki, K Fukuda - World journal of stem cells, 2015 - ncbi.nlm.nih.gov
Reprograming somatic cells using exogenetic gene expression represents a
groundbreaking step in regenerative medicine. Induced pluripotent stem cells (iPSCs) are …

Derivation of human induced pluripotent stem cell (iPSC) lines and mechanism of pluripotency: historical perspective and recent advances

A Chhabra - Stem Cell Reviews and Reports, 2017 - Springer
Derivation of human embryonic stem cell (hES) lines in 1998 was not only a major
technological breakthrough in the field of regenerative medicine; it also triggered a …

Derivation of transgene-free human induced pluripotent stem cells from human peripheral T cells in defined culture conditions

Y Kishino, T Seki, J Fujita, S Yuasa, S Tohyama… - PloS one, 2014 - journals.plos.org
Recently, induced pluripotent stem cells (iPSCs) were established as promising cell sources
for revolutionary regenerative therapies. The initial culture system used for iPSC generation …

[HTML][HTML] Pluripotent stem cell-based cell therapies: Current applications and future prospects

G Wang, P Heimendinger, RA Ramelmeier… - Current Opinion in …, 2022 - Elsevier
Recently, there has been a major uptick in the research and clinical development of
pluripotent stem cells (PSCs). This is due to human PSC's unique properties of unlimited self …

Pluripotent stem cells: immune to the immune system?

JI Pearl, LS Kean, MM Davis, JC Wu - Science translational medicine, 2012 - science.org
Human embryonic stem cells (hESCs), initially thought to be immune privileged cells, are
now known to be susceptible to immune recognition. Human induced pluripotent stem cells …