Background: There is growing evidence of the importance of genetic predisposition and the
activation of the mucosal immune system in the pathogenesis of inflammatory bowel …

Background Interleukin 1 (IL‐1) and its physiological antagonist interleukin‐1 receptor
antagonist (IL‐1ra) play a crucial role in the pathogenesis of inflammatory bowel disease …

Objective: Genetic susceptibility to inflammatory bowel disease is well recognized. There is
also increasing evidence for the activation of the mucosal immune system and the …

Recent reports have shown that allele 2 of the IL-1 receptor antagonist (IL-1Ra) gene is over-
represented in ulcerative colitis (UC). Healthy individuals carrying allele 2 of this gene have …

Background: Inflammatory bowel disease (IBD) is a chronic inflammation of the
gastrointestinal tract of unknown aetiology, phenotypically categorized into ulcerative colitis …

There is evidence of a disbalance in the inflammatory regulation of patients with
inflammatory bowel diseases (IBD). Interleukin-1β plays an important role in the pro …

Background—An imbalance between the proinflammatory cytokine interleukin 1β (IL-1β)
and the anti-inflammatory cytokine IL-1 receptor antagonist (IL-1ra) has been postulated as …

Background & Aims: The role of the interleukin (IL)-1 receptor antagonist (IL-1ra) in
predisposing an individual to inflammatory bowel disease (IBD) is controversial. This study …

Both genetic and environmental factors have been implicated in the etiology of inflammatory
bowel diseases (IBD) ie, Crohn's disease (CD) and ulcerative colitis (UC). Polymorphisms in …

BACKGROUND: Recently, the association of a polymorphism in the gene coding for the anti-
inflammatory cytokine interleukin-1 receptor antagonist with ulcerative colitis has been …