Peripheral nerve injury triggers the activation of the small GTPase RhoA in spinal motor and
peripheral sensory neurons. C3 transferase, an exoenzyme produced by Clostridium …

Peripheral nerve injury triggers the activation of RhoA in spinal motor and peripheral
sensory neurons. RhoA activates a number of effector proteins including the Rho-associated …

C3 exoenzyme from Clostridium botulinum, specifically ADP-ribosylates small GTP-binding
proteins RhoA, B, and C. ADP-ribosylation causes functional inactivation of Rho proteins …

C3 exoenzyme from Clostridium botulinum is the prototype of bacterial ADP-
ribosyltransferases, which selectively modifies the Rho isoforms RhoA, RhoB and RhoC by …

ABSTRACT Small GTPases of the Rho family play versatile roles in the formation and
development of axons and dendrites, effects often studied by the Rho‐inactivating C3 …

The identification of RhoA inhibition as a therapeutic target in neurodegenerative diseases
and traumatic central nervous system (CNS) injuries has introduced a need to develop tools …

J. Neurochem.(2012) 120, 1084–1096. Abstract C3 ADP‐ribosyltransferase is a valuable
tool to study Rho‐dependent cellular processes. In the current study we investigated the …

Formation of neurites and their differentiation into axons and dendrites requires precisely
controlled changes in the cytoskeleton. While small GTPases of the Rho family appear to be …

Functional recovery and regeneration of corticospinal tract (CST) fibers following spinal cord
injury by compression or dorsal hemisection in mice was monitored after application of the …

Clostridium botulinum exoenzyme C3 is the prototype of C3-like ADP-ribosyltransferases
that modify the GTPases RhoA, B, and C. C3 catalyzes the transfer of an ADP-ribose moiety …