Rabbits predominantly rearrange the most 3′ VH gene (VH1); thus combinatorial diversity
is very limited. In man and mouse, the most 3′ DH gene, DQ52, is preferentially rearranged …

The neonatal antibody repertoire in both mouse and humans differs from that of the adult
repertoire in that the neonatal repertoire uses a limited set of JH-proximal VH genes but the …

Extrachromosomal circular DNA purified from bone marrow cells of 2‐weeks‐old rabbits was
assayed by polymerase chain reaction to determine the relative rearrangement frequencies …

In this study, the contribution of the CD5+ B cell to the preferential expression of VH 7183
and Q52 observed early in development was determined. CD5+ and CD5-B cells from …

Polyclonal B cell leukemias have been generated in 17‐to 20‐day old Eμ‐myc transgenic
rabbits. To analyze the repertoire of VH genes utilized in early B cells, eight VDJ genes were …

B cells in rabbit preferentially utilize the 3'‐most VH gene, VH1, in VDJ genes. To determine
whether the preferential utilization of VH1 results from preferential rearrangement, we …

The process of V (D) J recombination that leads to the assembly of Ig gene segments is
tightly controlled during B cell differentiation. Two germline transcripts, one of which (μ 0) …

The exons encoding an expressed immunoglobulin (Ig) heavy chain variable region are
assembled from three types of gene segments: variable, Igh-V (Vn), diversity, lgh-D (DH) …

During B lymphocyte development, Ig heavy and L chain genes are assembled by V (D) J
recombination. Individual V, D, and J genes rearrange at very different frequencies in vivo …

The functional B cell repertoire in BALB/c mice was assessed at various stages in ontogeny.
This was done by analyzing VH gene family expression using the sensitive technique of in …