The C terminus of the histone chaperone Asf1 cross-links to histone H3 in yeast and promotes interaction with histones H3 and H4
The central histone H3/H4 chaperone Asf1 comprises a highly conserved globular core and
a divergent C-terminal tail. While the function and structure of the Asf1 core are well known …
a divergent C-terminal tail. While the function and structure of the Asf1 core are well known …
[PDF][PDF] Structure of the histone chaperone ASF1 bound to the histone H3 C-terminal helix and functional insights
M Agez, J Chen, R Guerois, C Van Heijenoort… - Structure, 2007 - cell.com
Asf1 is a histone chaperone that favors histone H3/H4 assembly and disassembly. We
solved the structure of the conserved domain of human ASF1A in complex with the C …
solved the structure of the conserved domain of human ASF1A in complex with the C …
[HTML][HTML] Structure of the yeast histone H3-ASF1 interaction: implications for chaperone mechanism, species-specific interactions, and epigenetics
AJ Antczak, T Tsubota, PD Kaufman, JM Berger - BMC structural biology, 2006 - Springer
Abstract Background The histone H3/H4 chaperone Asf1 (anti-silencing function 1) is
required for the establishment and maintenance of proper chromatin structure, as well as for …
required for the establishment and maintenance of proper chromatin structure, as well as for …
[HTML][HTML] Structural basis for the histone chaperone activity of Asf1
CM English, MW Adkins, JJ Carson, MEA Churchill… - Cell, 2006 - cell.com
Summary Anti-silencing function 1 (Asf1) is a highly conserved chaperone of histones H3/H4
that assembles or disassembles chromatin during transcription, replication, and repair. The …
that assembles or disassembles chromatin during transcription, replication, and repair. The …
[PDF][PDF] Gene-specific targeting of the histone chaperone asf1 to mediate silencing
The histone chaperone Asf1 assists in chromatin assembly and remodeling during
replication, transcription activation, and gene silencing. However, it has been unclear to …
replication, transcription activation, and gene silencing. However, it has been unclear to …
In vivo study of the nucleosome assembly functions of ASF1 histone chaperones in human cells
A Galvani, R Courbeyrette, M Agez… - … and cellular biology, 2008 - Am Soc Microbiol
Histone chaperones have been implicated in nucleosome assembly and disassembly as
well as histone modification. ASF1 is a highly conserved histone H3/H4 chaperone that …
well as histone modification. ASF1 is a highly conserved histone H3/H4 chaperone that …
Dominant Mutants of the Saccharomyces cerevisiae ASF1 Histone Chaperone Bypass the Need for CAF-1 in Transcriptional Silencing by Altering Histone and Sir …
Transcriptional silencing involves the formation of specialized repressive chromatin
structures. Previous studies have shown that the histone H3–H4 chaperone known as …
structures. Previous studies have shown that the histone H3–H4 chaperone known as …
Structural basis for the interaction of Asf1 with histone H3 and its functional implications
F Mousson, A Lautrette, JY Thuret… - Proceedings of the …, 2005 - National Acad Sciences
Asf1 is a conserved histone chaperone implicated in nucleosome assembly, transcriptional
silencing, and the cellular response to DNA damage. We solved the NMR solution structure …
silencing, and the cellular response to DNA damage. We solved the NMR solution structure …
[HTML][HTML] The conformational flexibility of the C-terminus of histone H4 promotes histone octamer and nucleosome stability and yeast viability
MS Chavez, JK Scorgie, BK Dennehey, S Noone… - Epigenetics & …, 2012 - Springer
Background The protein anti-silencing function 1 (Asf1) chaperones histones H3/H4 for
assembly into nucleosomes every cell cycle as well as during DNA transcription and repair …
assembly into nucleosomes every cell cycle as well as during DNA transcription and repair …
[HTML][HTML] Asf1, a loveseat for a histone couple
Y Bao, X Shen - Cell, 2006 - cell.com
In this issue of Cell, English et al.(2006) present the first crystal structure of a histone
chaperone (Asf1) bound to histones (the H3/H4 heterodimer). The structure provides …
chaperone (Asf1) bound to histones (the H3/H4 heterodimer). The structure provides …