To achieve a sequence-specific DNA cleavage by topoisomerase I, derivatives of the
antitumor drug camptothecin have been covalently linked to triple helix-forming …

Topoisomerase I is a ubiquitous DNA-cleaving enzyme and an important therapeutic target
in cancer chemotherapy for camptothecins (CPTs). These drugs stimulate DNA cleavage by …

There is considerable interest in the development of sequence-selective DNA drugs.
Chemical agents able to interfere with DNA topoisomerases-essential nuclear enzymes-are …

Topoisomerase I is an ubiquitous DNA cleaving enzyme and an important therapeutic target
in cancer chemotherapy for the camptothecins as well as for indolocarbazole antibiotics …

Topoisomerase I (topo I) is a ubiquitous DNA-cleaving enzyme and an important therapeutic
target in cancer chemotherapy. Camptothecins (CPTs) reversibly trap topo I in covalent …

The covalent linkage of a hairpin polyamide, which binds in the minor groove, to
camptothecin provides an efficient system to direct topoisomerase I mediated DNA cleavage …

Topoisomerase I is an ubiquitous DNA-cleaving enzyme and an important therapeutic target
in cancer chemotherapy for camptothecins as well as for indolocarbazole antibiotics such as …

The sequence-specific targeting of duplex DNA using triple helix-forming oligonucleotides
(TFOs) has attracted broad attention. 1 Currently, all such attempts to target DNA have used …

Topoisomerase I (Top1) activities are sensitive to various endogenous base modifications,
and anticancer drugs including the natural alkaloid camptothecin. Here, we show that triple …

Triplex-forming oligonucleotides (TFOs) are among the most specific DNA ligands and
represent an important tool for specific regulation of gene expression. TFOs have also been …